Effect of Different Doses of Nitrate Supplements on hepatocellular Damage Markers in Male Sprague Dawley Rats Following One Session of Exercise

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Yadsar M.; Shahabpour e.; Moradi Sarabi m.; KOUSHKIE JAHROMI M.

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Journal: Yafteh Year:2021 | Volume:23 | Issue:3 (88) Page(s): 119-133

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Title

Effect of Different Doses of Nitrate Supplements on hepatocellular Damage Markers in Male Sprague Dawley Rats Following One Session of Exercise

Author(s)

Yadsar M. | Shahabpour e. | Moradi Sarabi m. | KOUSHKIE JAHROMI M. | Issue Writer Certificate

Keywords

Alanine aminotransaminaseQ2

Aspartate aminotransaminaseQ1

AST/ALT ratioQ1

Eccentric exerciseQ1

Nitric oxideQ1

Abstract

Background: Hepatocellular damage caused by physical activity or the use of supplements is one of the serious problems facing athletes in various fields. This study aimed to evaluate the effect of different doses of Nitric oxide supplements on AST and ALT liver enzymes and the ratio of AST to ALT following a session of Eccentric exercise in Sprague Dawley male rats. Materials and Methods: In this study, 36 Sprague Dawleymale rats (two months old) were divided into three groups of control, low dose (4. 8 mg/kg body weight), and high dose of NO supplements (15. 4 mg/kg body weight). Supplements were given to rats for seven days. Subsequently, all three groups of rats were forced to run on a treadmill for 45 min with a speed of 20 m/min, and a slope of-15 degrees. Blood samples were taken directly from cardiac puncture of rats 24 h after the running exercise. Blood serum variables of the study were measured afterward. Results: Low dose of nitrate supplements did not change AST and ALT indices, while the high dose of nitrate supplements increased ALT serum level and decreased AST to ALT ratio, compared to a low dose of NO supplements and control group. Conclusion: Based on the obtained results, the consumption of a low dose of NO supplements does not change hepatocellular damage markers, while the high dose of NO supplements causes degeneration of hepatic cells in athletes.

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APA: Copy

Yadsar, M., Shahabpour, e., Moradi Sarabi, m., & KOUSHKIE JAHROMI, M.. (2021). Effect of Different Doses of Nitrate Supplements on hepatocellular Damage Markers in Male Sprague Dawley Rats Following One Session of Exercise. YAFTEH, 23(3 (88) ), 119-133. SID. https://sid.ir/paper/415012/en

Vancouver: Copy

Yadsar M., Shahabpour e., Moradi Sarabi m., KOUSHKIE JAHROMI M.. Effect of Different Doses of Nitrate Supplements on hepatocellular Damage Markers in Male Sprague Dawley Rats Following One Session of Exercise. YAFTEH[Internet]. 2021;23(3 (88) ):119-133. Available from: https://sid.ir/paper/415012/en

IEEE: Copy

M. Yadsar, e. Shahabpour, m. Moradi Sarabi, and M. KOUSHKIE JAHROMI, “Effect of Different Doses of Nitrate Supplements on hepatocellular Damage Markers in Male Sprague Dawley Rats Following One Session of Exercise,” YAFTEH, vol. 23, no. 3 (88) , pp. 119–133, 2021, [Online]. Available: https://sid.ir/paper/415012/en

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