Investegation of Factors Associated with Tcd4 + Lymphocyte Count Change and Survival Of HIV+ Patients Using Joint Model with Longitudinal and Survival Measurements

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Motevaseli Darab Sayeh; Aalmasi Afshin; SHAHSAVARI SOODEH; SHAKIBA EBRAHIM; Madreseh Elham

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Journal: Scientific Journal of Kurdistan University of Medical Sciences Year:2021 | Volume:26 | Issue:4 (114) Page(s): 59-68

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Title

Investegation of Factors Associated with Tcd4 + Lymphocyte Count Change and Survival Of HIV+ Patients Using Joint Model with Longitudinal and Survival Measurements

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Keywords

Joint modelQ2

Longitudinal measurementsQ1

SurvivalQ1

HIVQ2

TCD4++Q1

Abstract

Background and Aim: Human immunodeficiency virus (HIV) is now a major global health problem. The aim of this study was to determine factors affecting the change in TCD4++ lymphocyte count and Survival of HIV patients simultaneously in Kermanshah Province, using a Joint model for longitudinal and Survival time measurements. Materials and Methods: In this retrospective cohort study we extracted data of 614 HIV+ patients receiving antiretroviral therapy from the Registry of Behavioral Disease Counseling Center of Kermanshah Province from 2001 to 2018. Data included variables of longitudinal TCD4++ and Survival of patients (time interval from HIV diagnosis to death) as response. Then, using a Joint model, the relationship between TCD4++ and the Survival of patients was determined. Data analysis was performed using R (3. 4. 3) software package JM. P< 0. 05 was considered significant. Results: In the Joint model, sex, age at the time of diagnosis, marital status, history of addiction, education level, time, and presence of tuberculosis had a significant relationship with TCD4++ lymphocyte count (p<0. 05). Tuberculosis (HR=2. 624) was an effective risk factor for death of HIV patients (p<0. 001). There was a significant relationship between the two responses (p<0. 001) so that 1-unit decrease in the number of TCD4++ lymphocytes led to a 36. 5% increase in the risk of death over time. Conclusion: Since HIV+ patients are exposed to the risk of development of tuberculosis, a decrease in the number of TCD4+ + lymphocytes may be a good prognostic indicator for death in HIV patients.

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APA: Copy

Motevaseli Darab, Sayeh, Aalmasi, Afshin, SHAHSAVARI, SOODEH, SHAKIBA, EBRAHIM, & Madreseh, Elham. (2021). Investegation of Factors Associated with Tcd4 + Lymphocyte Count Change and Survival Of HIV+ Patients Using Joint Model with Longitudinal and Survival Measurements. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, 26(4 (114) ), 59-68. SID. https://sid.ir/paper/415015/en

Vancouver: Copy

Motevaseli Darab Sayeh, Aalmasi Afshin, SHAHSAVARI SOODEH, SHAKIBA EBRAHIM, Madreseh Elham. Investegation of Factors Associated with Tcd4 + Lymphocyte Count Change and Survival Of HIV+ Patients Using Joint Model with Longitudinal and Survival Measurements. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2021;26(4 (114) ):59-68. Available from: https://sid.ir/paper/415015/en

IEEE: Copy

Sayeh Motevaseli Darab, Afshin Aalmasi, SOODEH SHAHSAVARI, EBRAHIM SHAKIBA, and Elham Madreseh, “Investegation of Factors Associated with Tcd4 + Lymphocyte Count Change and Survival Of HIV+ Patients Using Joint Model with Longitudinal and Survival Measurements,” SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 4 (114) , pp. 59–68, 2021, [Online]. Available: https://sid.ir/paper/415015/en

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