High level serum Inhibin-A in 1 pregnancy trimesters as a risk factor for adverse pregnancy outcomes: a systematic review and metaanalysis

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Faraji Azam; ALBORZI SAEED; Moradi Alamdarloo Shaghayegh; KASRAEIAN MARYAM; VAFAEI HOMEIRA; ASADI NASRIN; ZARE MARJAN

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Journal: Pars Journal of Medical Sciences Year:2021 | Volume:18 | Issue:4 Page(s): 25-34

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Title

High level serum Inhibin-A in 1 pregnancy trimesters as a risk factor for adverse pregnancy outcomes: a systematic review and metaanalysis

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Keywords

Inhibin AQ1

PregnancyQ2

Systematic ReviewQ1

Meta-AnalysisQ1

Abstract

Introduction: Naturaly; Inhibin-A plays an important role in the reproduction, and its abnormal level can be associated with the risk of adverse Pregnancy outcomes. The aim of the current study was to evaluate the effect of high level serum Inhibin-A in the first and second Pregnancy trimesters on adverse Pregnancy outcomes doing a Systematic Review and Meta-Analysis. Material and Methods: In a systematic search done in PubMed, Embrace, Magiran, Irandoc, Web of Science, Scopus, and Google Scholar in Persian and English languages since year 2000, seven articles were extracted and entered in the Meta-Analysis. Finally, odds ratio and confidence intervale were reported. Results: The current Meta-Analysis showed that high level of Inhibin-A increased the odds of preeclampsia (OR= 9. 77, 95% C. I: 3. 88-24. 62); however, it did not affect on cesarean section delivery (OR= 1. 06, 95% C. I: 0. 80-1. 41). As adverse Pregnancy outcomes addressing the fetus and new born, high level of serum Inhibin A incresed the odds of low birth weight (OR=7. 34, 95% C. I: 4. 4-12. 23), preterm birth (OR=5. 18, 95% C. I: 1. 89-14. 17), and fetal growth retardation (OR=2. 77, 95% C. I: 1. 78-4. 30). Conclusion: High level serum Inhibin-A in the first and second Pregnancy trimesters increases the odds of preeclampsia, preterm birth, fetal growth retardation, and low birth weight; however, it does not effect on cesarean section.

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APA: Copy

Faraji, Azam, ALBORZI, SAEED, Moradi Alamdarloo, Shaghayegh, KASRAEIAN, MARYAM, VAFAEI, HOMEIRA, ASADI, NASRIN, & ZARE, MARJAN. (2021). High level serum Inhibin-A in 1 pregnancy trimesters as a risk factor for adverse pregnancy outcomes: a systematic review and metaanalysis. PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL), 18(4 ), 25-34. SID. https://sid.ir/paper/415031/en

Vancouver: Copy

Faraji Azam, ALBORZI SAEED, Moradi Alamdarloo Shaghayegh, KASRAEIAN MARYAM, VAFAEI HOMEIRA, ASADI NASRIN, ZARE MARJAN. High level serum Inhibin-A in 1 pregnancy trimesters as a risk factor for adverse pregnancy outcomes: a systematic review and metaanalysis. PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL)[Internet]. 2021;18(4 ):25-34. Available from: https://sid.ir/paper/415031/en

IEEE: Copy

Azam Faraji, SAEED ALBORZI, Shaghayegh Moradi Alamdarloo, MARYAM KASRAEIAN, HOMEIRA VAFAEI, NASRIN ASADI, and MARJAN ZARE, “High level serum Inhibin-A in 1 pregnancy trimesters as a risk factor for adverse pregnancy outcomes: a systematic review and metaanalysis,” PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL), vol. 18, no. 4 , pp. 25–34, 2021, [Online]. Available: https://sid.ir/paper/415031/en

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