Cytotoxicity Effects of Green Synthesized Silver Nanoparticles by Using the Extract of Tuber Spp. on Breast Cancer (MCF-7) Cells

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NEDAEI SH.; AKBARI H.; YAGHOUBI H.

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Paper Information

Journal: JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS) Year:2019 | Volume:21 | Issue:1 Page(s): 242-248

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Title

Cytotoxicity Effects of Green Synthesized Silver Nanoparticles by Using the Extract of Tuber Spp. on Breast Cancer (MCF-7) Cells

Author(s)

NEDAEI SH. | AKBARI H. | YAGHOUBI H. | Issue Writer Certificate

Keywords

Silver NanoparticlesQ1

Truffle Fungus(Tuber spp.)Q1

Bio-synthesisQ1

MTTQ2

MCF-7 Cell LineQ1

Abstract

BACKGROUND AND OBJECTIVE: Silver Nanoparticles have antibacterial and anticancer activity. But the organic solvents used to produce these nanoparticles are toxic and can have devastating environmental effects. Therefore, there is a strong desire to use healthy methods for the synthesis of Silver Nanoparticles. Therefore, this study was performed to synthesize Silver Nanoparticles biologically from aqueous extract of Truffle and to study their biological effects on cancer cells. METHODS: In this experimental study, to synthesize Silver Nanoparticles from aqueous extract of Truffle, 10 ml of fungus extract was added to 90 ml of 1 ml silver nitrate solution and incubated for 72 hours at room temperature. The physicochemical properties of the nanoparticles synthesized by XRD, FESEM and TEM were analyzed. Effects of Extract and Synthesized Nanoparticles were studied by MTT at concentrations of 0. 025, 0. 25, 0. 25, 0. 5 and 1 mg / ml on MCF-7 Cancer Cells at 72, 48, and 24 hours. FINDINGS: The size of the nanoparticles was between 19 and 35 nm and their shape was mainly spherical. In cytotoxicity assay using MTT assay IC50 calculated for Silver Nanoparticles and extract in MCF-7 cells showed that Silver Nanoparticles had more cytotoxic effects than extract. The calculated IC50 for extracts and nanoparticles at 24, 48 and 72 hours were 0. 73, 0. 8, and 0. 64 mg / ml, respectively, and for the nanoparticles were 0. 6, 0. 5, and 0. 48, respectively (p <0. 05). CONCLUSION: The Silver Nanoparticles produced by Bio-synthesis method have a higher cytotoxicity than the truffle fungus (Tuber spp. ) extract.

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APA: Copy

NEDAEI, SH., AKBARI, H., & YAGHOUBI, H.. (2019). Cytotoxicity Effects of Green Synthesized Silver Nanoparticles by Using the Extract of Tuber Spp. on Breast Cancer (MCF-7) Cells. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), 21(1 ), 242-248. SID. https://sid.ir/paper/415211/en

Vancouver: Copy

NEDAEI SH., AKBARI H., YAGHOUBI H.. Cytotoxicity Effects of Green Synthesized Silver Nanoparticles by Using the Extract of Tuber Spp. on Breast Cancer (MCF-7) Cells. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS)[Internet]. 2019;21(1 ):242-248. Available from: https://sid.ir/paper/415211/en

IEEE: Copy

SH. NEDAEI, H. AKBARI, and H. YAGHOUBI, “Cytotoxicity Effects of Green Synthesized Silver Nanoparticles by Using the Extract of Tuber Spp. on Breast Cancer (MCF-7) Cells,” JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), vol. 21, no. 1 , pp. 242–248, 2019, [Online]. Available: https://sid.ir/paper/415211/en

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