THE EFFECTS OF INTERVAL TRAINING INTENSITY ON SKELETAL MUSCLE PGC1A IN TYPE2 DIABETIC MALE RATS

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Tabari Elma; MOHEBBI HAMID; KARIMI POURAN; Moghaddami Kamilia; KHALAFI MOUSA

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Journal: Iranian Journal of Diabetes and Metabolism Year:2019 | Volume:18 | Issue:4 Page(s): 179-188

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Title

THE EFFECTS OF INTERVAL TRAINING INTENSITY ON SKELETAL MUSCLE PGC1A IN TYPE2 DIABETIC MALE RATS

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Keywords

Type 2 DiabetesQ1

Interval TrainingQ1

Training IntensityQ1

Pgc-1αQ1

Mitochondrial BiogenesisQ1

Abstract

Background: The purpose of this study was to compare the effects of a 12 weeks Interval Training with high and moderate intensity on Pgc-1α of skeletal muscle in type 2 diabetic male rats. Methods: 40 male rats were divided into two groups: High fat diet (HFD) (n=32) and standard diet (C) (n=8) for 10 weeks. After inducing type2 diabetes via STZ, 8 diabetic rats (D) and 8 rats in group C rats sacrificed and the remaining 24 Rats were randomly assigned to three groups of diabetic control (DC), moderate intensity Interval Training (MIIT) and high intensity Interval Training (HIIT). The MIIT protocol includes 13 bouts of 4minute activity with equivalent intensity of 60-65% vo2max and the HIIT protocol includes 10 bouts of 4minute activity with equivalent intensity of 85-90% vo2max with 2 minute active rest periods that was applied for 12 weeks, 5 sessions per week. Western Blot method was used to measure Pgc-1α protein levels. Results: The results showed that Pgc-1α protein levels were significantly lower in the D group compared to the HC group. In contrast, the HIIT protocol resulted in an increase in protein levels of Pgc-1α compared to DC2 group. While MICT had no significant effect on protein levels of Pgc-1α (P <0. 05). Also, there was no significant difference between the two training groups (P<0. 05). Conclusion: It seems that the intensity of Interval Training plays an important role in the regulation of skeletal muscle Pgc-1α and possibly mitochondria biogenesis in type 2 diabetic rats.

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APA: Copy

Tabari, Elma, MOHEBBI, HAMID, KARIMI, POURAN, Moghaddami, Kamilia, & KHALAFI, MOUSA. (2019). THE EFFECTS OF INTERVAL TRAINING INTENSITY ON SKELETAL MUSCLE PGC1A IN TYPE2 DIABETIC MALE RATS. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 18(4 ), 179-188. SID. https://sid.ir/paper/415474/en

Vancouver: Copy

Tabari Elma, MOHEBBI HAMID, KARIMI POURAN, Moghaddami Kamilia, KHALAFI MOUSA. THE EFFECTS OF INTERVAL TRAINING INTENSITY ON SKELETAL MUSCLE PGC1A IN TYPE2 DIABETIC MALE RATS. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2019;18(4 ):179-188. Available from: https://sid.ir/paper/415474/en

IEEE: Copy

Elma Tabari, HAMID MOHEBBI, POURAN KARIMI, Kamilia Moghaddami, and MOUSA KHALAFI, “THE EFFECTS OF INTERVAL TRAINING INTENSITY ON SKELETAL MUSCLE PGC1A IN TYPE2 DIABETIC MALE RATS,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 18, no. 4 , pp. 179–188, 2019, [Online]. Available: https://sid.ir/paper/415474/en

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