EVALUATION OF SERUM CHITINASE-3 LIKE 1 PROTEIN AND C-REACTIVE PROTEIN LEVELS IN TYPE 2 DIABETES MELLITUS WITH CORONARY ARTERY DISEASE COMPARED TO DIABETIC AND HEALTHY CONTROL

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Jafari Nadoushan Gholamreza; HADINEDOUSHAN HOSSEIN; NAMIRANIAN NASIM; REZAEI SAEID

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Journal Paper

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Journal: Iranian Journal of Diabetes and Metabolism Year:2019 | Volume:18 | Issue:5 Page(s): 246-256

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Title

EVALUATION OF SERUM CHITINASE-3 LIKE 1 PROTEIN AND C-REACTIVE PROTEIN LEVELS IN TYPE 2 DIABETES MELLITUS WITH CORONARY ARTERY DISEASE COMPARED TO DIABETIC AND HEALTHY CONTROL

Author(s)

Jafari Nadoushan Gholamreza | HADINEDOUSHAN HOSSEIN | NAMIRANIAN NASIM | REZAEI SAEID | Issue Writer Certificate

Keywords

YKL-40Q1

hs-CRPQ2

Diabetes type 2Q1

AtherosclosisQ2

Abstract

Background: Diabetes mellitus, which is associated with elevated blood glucose, lipids and liver enzymes, may results in alterations in the production of inflammatory cytokines, including chitinase-3-like protein 1 (YKL-40) and high-sensitivity C-reactive protein (hs-CRP), which induce and promote complications of diabetes such as atherosclerosis. The aim of this study was to evaluate the serum level of chitinase-3 like 1 protein (YKL-40) and high-sensitive C-reactive protein (hs-CRP) in type 2 diabetes with coronary artery disease compared to diabetic and healthy control. Methods: This cross-sectional study was performed on 87 subjects in four groups, including: 23 samples as healthy control (Group 1), 22 patients with type 2 diabetes (Group 2), 20 patients with coronary artery disease (Group 3) and 22 patients with type 2 diabetes and coronary artery disease (Group 4). Serum Fasting blood sugar (FBS), Cholesterol, Triglyceride, Low density lipoprotein (LDL-C), High density lipoprotein (HDL-C), Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), YKL-40 and hs-CRP were determined. Results: The mean serum levels of FBS (Group 1 with 2 and 4, Group 2 and 3, P = 0. 001), Cholesterol (Group 1 and 3, P = 0. 03), Triglyceride (Group 2 and 3, p=0. 027), HDL-C (Group 1 with 3 and 4, P = 0. 02, P = 0. 01 respectively), ALT (Group 1 and 4, P = 0. 03, Group 2 and 4, P = 0. 02) and AST (Group 2 and 4, P = 0. 009) were significantly different. . The mean serum levels of YKL-40 were significantly difference in the group 1(4. 81± 1. 27 ng/ml) and group 2 (15. 52± 4. 61 ng/ml) (P=0. 01), group 3 (19. 2± 2. 75 ng/ml, P=0. 017) and group 4 (16. 1± 4. 17 ng/ml, P=0. 04). Also, The mean serum levels of hs-CRP in the group 3 (4. 49± 1. 53 μ g/ml) and group 4 (1. 28 ± 0. 43 μ g/ml) was significantly difference (P= 0. 028). Conclusion: Serum levels of YKL-40 are increased in people with type 2 diabetes and coronary artery disease. It is recommended to determine the serum level of this marker in these patients.

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APA: Copy

Jafari Nadoushan, Gholamreza, HADINEDOUSHAN, HOSSEIN, NAMIRANIAN, NASIM, & REZAEI, SAEID. (2019). EVALUATION OF SERUM CHITINASE-3 LIKE 1 PROTEIN AND C-REACTIVE PROTEIN LEVELS IN TYPE 2 DIABETES MELLITUS WITH CORONARY ARTERY DISEASE COMPARED TO DIABETIC AND HEALTHY CONTROL. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 18(5 ), 246-256. SID. https://sid.ir/paper/415483/en

Vancouver: Copy

Jafari Nadoushan Gholamreza, HADINEDOUSHAN HOSSEIN, NAMIRANIAN NASIM, REZAEI SAEID. EVALUATION OF SERUM CHITINASE-3 LIKE 1 PROTEIN AND C-REACTIVE PROTEIN LEVELS IN TYPE 2 DIABETES MELLITUS WITH CORONARY ARTERY DISEASE COMPARED TO DIABETIC AND HEALTHY CONTROL. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2019;18(5 ):246-256. Available from: https://sid.ir/paper/415483/en

IEEE: Copy

Gholamreza Jafari Nadoushan, HOSSEIN HADINEDOUSHAN, NASIM NAMIRANIAN, and SAEID REZAEI, “EVALUATION OF SERUM CHITINASE-3 LIKE 1 PROTEIN AND C-REACTIVE PROTEIN LEVELS IN TYPE 2 DIABETES MELLITUS WITH CORONARY ARTERY DISEASE COMPARED TO DIABETIC AND HEALTHY CONTROL,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 18, no. 5 , pp. 246–256, 2019, [Online]. Available: https://sid.ir/paper/415483/en

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