مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

234
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

0
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

THE EFFECT OF INTENSE PERIODIC EXERCISE AND CONSUMPTION OF BLACK GRAPE SEED EXTRACT ON BAX AND BCL-2 GENE EXPRESSION IN PANCREATIC TISSUE OF MALE RATS WITH TYPE 2 DIABETES

Pages

  105-116

Keywords

Intense Intermittent Exercise (HIIT)Q1

Abstract

 Background: Although some studies have studied the mechanism of action of beta cells in animal models and more or less in human populations, but so far the role of exercise therapy or exercise exercise HIIT with black grape supplementation on the expression of genes involved in pancreatic beta cells This study investigates the effect of black grape supplementation combined with intense intermittent exercise on Bcl-2 and Bax genes in pancreatic tissue of rats with type 2 Diabetes. Methods: The study was conducted in the form of an experimental design. The subjects of this project were 40 8-month-old male rats with an average weight of 250 grams. After familiarizing the subjects with exercise and induction of Diabetes by STZ, the subjects were randomly divided into 5 groups including exercise, supplement, exercise and supplement, diabetic control and basic control. After 8 weeks of training, which was 5 sessions per week for 8 weeks, the activity was on a treadmill with an intensity of 90% Vo2max and supplementation with Black Grape Seed Extract. Bcl-2 and Bax genes were measured after RNA extraction from Pancreas and cDNA synthesis. Bcl-2 and Bax genes were measured by Time-Real PCR. Data were analyzed using independent t-test and two-factor analysis of variance at the significance level of 0. 05 by SPSS software version 24. Results: The results showed that the main effect of exercise had no significant effect on Bcl-2 gene expression. The main effect of the extract on the expression of this gene was significant. Also, the interaction between exercise and Bcl-2 supplementation was not significant. Regarding Bax gene expression, it was shown that the main effect of exercise on the gene was significant. The main effect of extract and interaction of exercise and supplementation on Bax gene expression was not significant. No significant changes were observed in the effect of exercise and extract on the expression of Bcl-2 and Bax genes. Conclusion: It seems that regulating the expression of Bcl-2 and Bax genes through exercise and consumption of Black Grape Seed Extract is likely to improve and maintain pancreatic beta cell function in diabetic rats.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    Abdi, Homna, Alijani, Eidi, & MOHSENZADEH, MAHSA. (2021). THE EFFECT OF INTENSE PERIODIC EXERCISE AND CONSUMPTION OF BLACK GRAPE SEED EXTRACT ON BAX AND BCL-2 GENE EXPRESSION IN PANCREATIC TISSUE OF MALE RATS WITH TYPE 2 DIABETES. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 20(2 ), 105-116. SID. https://sid.ir/paper/415561/en

    Vancouver: Copy

    Abdi Homna, Alijani Eidi, MOHSENZADEH MAHSA. THE EFFECT OF INTENSE PERIODIC EXERCISE AND CONSUMPTION OF BLACK GRAPE SEED EXTRACT ON BAX AND BCL-2 GENE EXPRESSION IN PANCREATIC TISSUE OF MALE RATS WITH TYPE 2 DIABETES. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2021;20(2 ):105-116. Available from: https://sid.ir/paper/415561/en

    IEEE: Copy

    Homna Abdi, Eidi Alijani, and MAHSA MOHSENZADEH, “THE EFFECT OF INTENSE PERIODIC EXERCISE AND CONSUMPTION OF BLACK GRAPE SEED EXTRACT ON BAX AND BCL-2 GENE EXPRESSION IN PANCREATIC TISSUE OF MALE RATS WITH TYPE 2 DIABETES,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 20, no. 2 , pp. 105–116, 2021, [Online]. Available: https://sid.ir/paper/415561/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button