The effect of Platelet Rich Plasma (PRP) on the B92 Glial Cell

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Pourkamalzadeh Mahtab; ABTAHI FROUSHANI SEYYED MEYSAM; Mahmoudian Alireza

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Journal Paper

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Journal: Journal of Sabzevar University of Medical Sciences Year:2021 | Volume:28 | Issue:2 Page(s): 173-181

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Title

The effect of Platelet Rich Plasma (PRP) on the B92 Glial Cell

Author(s)

Pourkamalzadeh Mahtab | ABTAHI FROUSHANI SEYYED MEYSAM | Mahmoudian Alireza | Issue Writer Certificate

Keywords

Platelet-Rich Plasma (PRP)Q1

B92 Glial CellsQ1

IL-10Q1

TNF-ΑQ1

BCL-2Q1

Abstract

Introduction: In previous studies, the crosstalk between some cancer cells and platelets have been documented. The purpose of the present study was to evaluate the effects of platelet-rich plasma (PRP) on B92 glial cancer cells. Materials and Methods: In this experimental study, 1×106 B92 cells were treated with Platelet-rich plasma (PRP) for different of 0, 5, 10 and 20 percent of cutler media for 24 h. The morphological changes of the treated cells were evaluated by inverted light microscopy. The effects of PRP on the proliferation rate of cells were measured using the tetrazolium salt reduction test (dimethyl thiazole-diphenyltetrazolium bromide, MTT). QRT-PCR technique was used to evaluate the expression level of TNFα , IL-10 and BCL-2 genes. Results: The results of the MTT reduction test showed that PRP promotes B92 glial cell growth in a dose-dependent manner. PRP in a dose-dependent manner also increased BCL-2 gene expression. The expression of the TNF-α cytokine gene was decreased in a non-percent-dependent manner after the treatment of B92 Glial Cells with PRP. Treatment of B92 Glial Cells with PRP promoted a significant increase in the expression level of the gene of anti-inflammatory IL-10 cytokine. Conclusion: In the microenvironment of cancer, platelets promote the growth and proliferation of B92 Glial Cells and their escape from immune responses.

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APA: Copy

Pourkamalzadeh, Mahtab, ABTAHI FROUSHANI, SEYYED MEYSAM, & Mahmoudian, Alireza. (2021). The effect of Platelet Rich Plasma (PRP) on the B92 Glial Cell. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 28(2 ), 173-181. SID. https://sid.ir/paper/415817/en

Vancouver: Copy

Pourkamalzadeh Mahtab, ABTAHI FROUSHANI SEYYED MEYSAM, Mahmoudian Alireza. The effect of Platelet Rich Plasma (PRP) on the B92 Glial Cell. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2021;28(2 ):173-181. Available from: https://sid.ir/paper/415817/en

IEEE: Copy

Mahtab Pourkamalzadeh, SEYYED MEYSAM ABTAHI FROUSHANI, and Alireza Mahmoudian, “The effect of Platelet Rich Plasma (PRP) on the B92 Glial Cell,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 2 , pp. 173–181, 2021, [Online]. Available: https://sid.ir/paper/415817/en

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