THE EFFECT OF CLOFIBRATE ON NEONATAL JAUNDICE

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GHOTBI F.; TAGHILOU M.; GASHB A.

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Journal: Research in Medicine Year:2009 | Volume:33 | Issue:1 Page(s): 31-34

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Information Journal Paper

Title

THE EFFECT OF CLOFIBRATE ON NEONATAL JAUNDICE

Author(s)

GHOTBI F. | TAGHILOU M. | GASHB A. | Issue Writer Certificate

Keywords

NEONATAL JAUNDICEQ2

CLOFIBRATEQ3

NON-HEMOLYTIC HYPERBILLIRUBINEMIAQ3

RCTQ3

Abstract

Background: Hyperbilirubinemia is a common problem in newborn infants and may progress to kernicterus if not treated. The objective of this study was to determine the therapeutic effect of CLOFIBRATE in full-term healthy neonates with non-hemolytic hyperbilirubinemia. Material and method: A randomized clinical trial was performed on two groups of healthy full-term neonates with jaundice. CLOFIBRATE group, (n=50), received a single dose of oral CLOFIBRATE (100mg/kg), plus phototherapy, while the control group (n=50), received only phototherapy. Results: The mean plasma total bilirubin levels at 12, 24, and 48 hours after treatment were significantly lower in the CLOFIBRATE treated group, as compared with the control group (p=0.001). At 48 hours of treatment, 48% of patients in the CLOFIBRATE group, had bilirubin levels <12 mg/dl in comparison with 16% of control group (p=0.001). Treatment with CLOFIBRATE also resulted in a shorter duration of hospital stay as compared to the control group (p=0.001). Conclusion: A single oral dose of CLOFIBRATE (100mg/kg), along with phototherapy is more effective than phototherapy alone in treatment of non-hemolytic hyperbilirubinemia in full-term healthy newborn infants.

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APA: Copy

GHOTBI, F., TAGHILOU, M., & GASHB, A.. (2009). THE EFFECT OF CLOFIBRATE ON NEONATAL JAUNDICE. PAJOUHESH DAR PEZESHKI, 33(1), 31-34. SID. https://sid.ir/paper/41585/en

Vancouver: Copy

GHOTBI F., TAGHILOU M., GASHB A.. THE EFFECT OF CLOFIBRATE ON NEONATAL JAUNDICE. PAJOUHESH DAR PEZESHKI[Internet]. 2009;33(1):31-34. Available from: https://sid.ir/paper/41585/en

IEEE: Copy

F. GHOTBI, M. TAGHILOU, and A. GASHB, “THE EFFECT OF CLOFIBRATE ON NEONATAL JAUNDICE,” PAJOUHESH DAR PEZESHKI, vol. 33, no. 1, pp. 31–34, 2009, [Online]. Available: https://sid.ir/paper/41585/en

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