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Information Journal Paper

Title

Cytotoxic effect of curcumin on viability and P21 and Bcl-2 genes expression of the human anaplastic thyroid Carcinoma cells line (SW-1736)

Pages

  1-10

Abstract

 Background & Aim: Anaplastic Thyroid carcinoma (ATC) is an uncommon malignancy of the Thyroid. with poor prognosis and 2 to 6 month of survival time. The aim of this study was to explore the effect of Curcumin on bioavailability and expression of p21 and Bcl-2 genes in human anaplastic Thyroid carcinoma cell line (SW-1736). Methods: In this study, human anaplastic Thyroid carcinoma (SW-1736) cell line were cultured in RPMI-1640 medium with 10% bovine serum. The cells were treated with different concentration (2. 5, 5, 7. 5, 10 μ M) of Curcumin and incubated for 24 and 48 hours. Bioavailability was analyzed by MTS kit. The expression of p21 and Bcl-2 genes were investigated after 24, 48 and 72 hours by Real Time-PCR analysis in treated anaplastic Thyroid carcinoma cell line. Results: The results of the MTS assay indicate that the treatment with concentration of 7. 5 mM of Curcumin at both incubation times significantly reduced the bioavailability of the anaplastic Thyroid cells compared to the control and other experimental groups. Furthermore, the p21 and Bcl-2 genes expression were significantly changed in treatment with 2. 5, 5, 7. 5 and 10 μ M concentrations of Curcumin for 24, 48 and 72 hours, compared to control group. Conclusion: Curcumin has an inhibitory effect on the growth and proliferation of anaplastic Thyroid cancer cells.

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    Cite

    APA: Copy

    Tavakoli, Parinaz, ROUHI, LEILA, Raisi, Somayee, & Khashei Varnamkhasti, Khalil. (2021). Cytotoxic effect of curcumin on viability and P21 and Bcl-2 genes expression of the human anaplastic thyroid Carcinoma cells line (SW-1736). JOURNAL OF TORBAT HEYDARIYEH UNIVERSITY OF MEDICAL SCIENCES, 9(1 ), 1-10. SID. https://sid.ir/paper/416047/en

    Vancouver: Copy

    Tavakoli Parinaz, ROUHI LEILA, Raisi Somayee, Khashei Varnamkhasti Khalil. Cytotoxic effect of curcumin on viability and P21 and Bcl-2 genes expression of the human anaplastic thyroid Carcinoma cells line (SW-1736). JOURNAL OF TORBAT HEYDARIYEH UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2021;9(1 ):1-10. Available from: https://sid.ir/paper/416047/en

    IEEE: Copy

    Parinaz Tavakoli, LEILA ROUHI, Somayee Raisi, and Khalil Khashei Varnamkhasti, “Cytotoxic effect of curcumin on viability and P21 and Bcl-2 genes expression of the human anaplastic thyroid Carcinoma cells line (SW-1736),” JOURNAL OF TORBAT HEYDARIYEH UNIVERSITY OF MEDICAL SCIENCES, vol. 9, no. 1 , pp. 1–10, 2021, [Online]. Available: https://sid.ir/paper/416047/en

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