Investigation of CD44 Gene Expression in People with Lung Cancer in Tehran

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Ahmadzadeh Chaleshtari Z.; ZIA JAHROMI N.

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Information Journal Paper

Title

Investigation of CD44 Gene Expression in People with Lung Cancer in Tehran

Author(s)

Ahmadzadeh Chaleshtari Z. | ZIA JAHROMI N. | Issue Writer Certificate

Keywords

Lung cancerQ2

CD44Q2

gene expressionQ2

Real Time RT-PCRQ1

Abstract

Background & Objective: CD44 is a cellular protein that has been extensively studied for carcinogenicity over the past decade, so the aim of this study is to investigate the expression of CD44 gene in people with Lung cancer. Materials & Methods: 30 tissue samples were taken from the lung tumor and 30 samples were taken from healthy lung tissues. RNA samples were extracted and used for cDNA synthesis. The Real Time RT-PCR test with the GAPDH internal control gene was used to assess CD44 gene expression. Results: CD44 gene expression in tumor tissues, men, age group over 60 years, smokers and adenoma tumor, respectively 1. 2, 1. 4, 1. 1, 1. 9 and 1. 1 times higher than healthy samples, women, age group Under 60 years of age, non-smokers had SCC tumors. Conclusion: Inflammation caused by Lung cancer increased the production of CD44 inflammatory factor and thus increased its expression. Evaluating the expression of CD44 gene can be used as a marker to predict Lung cancer.

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APA: Copy

Ahmadzadeh Chaleshtari, Z., & ZIA JAHROMI, N.. (2021). Investigation of CD44 Gene Expression in People with Lung Cancer in Tehran. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, 10(4 ), 3074-3084. SID. https://sid.ir/paper/416111/en

Vancouver: Copy

Ahmadzadeh Chaleshtari Z., ZIA JAHROMI N.. Investigation of CD44 Gene Expression in People with Lung Cancer in Tehran. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES[Internet]. 2021;10(4 ):3074-3084. Available from: https://sid.ir/paper/416111/en

IEEE: Copy

Z. Ahmadzadeh Chaleshtari, and N. ZIA JAHROMI, “Investigation of CD44 Gene Expression in People with Lung Cancer in Tehran,” JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, vol. 10, no. 4 , pp. 3074–3084, 2021, [Online]. Available: https://sid.ir/paper/416111/en

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