Effect of Chronic Caffeine Administration on Expression Ratio of Bax and Bcl-2 Proteins in Myocardial Tissue of Male Wistar Rats With Type 2 Diabetes

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ZARGHAMI KHAMENEH ALI; JAFARI AFSHAR; NIKOOKHESLAT SAEED; KARIMI POURAN

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Journal: Complementary Medicine Journal Year:2020 | Volume:10 | Issue:3 (36) Page(s): 206-217

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Information Journal Paper

Title

Effect of Chronic Caffeine Administration on Expression Ratio of Bax and Bcl-2 Proteins in Myocardial Tissue of Male Wistar Rats With Type 2 Diabetes

Author(s)

ZARGHAMI KHAMENEH ALI | JAFARI AFSHAR | NIKOOKHESLAT SAEED | KARIMI POURAN | Issue Writer Certificate

Keywords

CaffeineQ1

ApoptosisQ1

Type 2 diabetesQ2

MyocardiumQ1

Abstract

Objective Some previous studies have shown the protective effect of Caffeine on Apoptosis through the regulation of pro-and anti-apoptotic proteins. The aim of this study was to investigate the effects of chronic Caffeine administration on the expression ratio of B-cell lymphoma protein 2 (Bcl-2) and Bcl-2-Associated X-protein (Bax) proteins in the cardiac tissue of rats with Type 2 diabetes. Methods In this experimental study, samples were 24 male white wistar rats (aged 2-3 months with a weight of 250-300 g) randomly divided into three groups: Healthy control (n=8), untreated diabetic (n=8), and diabetic with Caffeine supplement (n=8; 70 mg/kg-1 for 8 weeks, 5 days a week). The expression of proteins associated with apoptotic signaling pathway (Bax and Bcl-2) in the cardiac muscle (left ventricular) was measured by Western blot method. One-Way Variance (ANOVA), t-test, and Tukey’ s post hoc test were used for data analysis. Results Induction of type two diabetes significantly increased the expression of Bax protein (1. 81± 0. 2) and decreased the expression of Bcl-2 protein (0. 36± 0. 05) compared to control group (P=0. 001). However, Caffeine administration increased the expression of Bax protein (131%) compared to diabetic control group (P=0. 001). Therefore, Caffeine administration after diabetes induction elevated the Bax/Bcl-2 ratio (P=0. 001). Conclusion Eight weeks of Caffeine administration have an exacerbating effect on the apoptotic cell death caused by Type 2 diabetes by increasing pro-apoptotic proteins and reducing anti-apoptotic proteins...

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APA: Copy

ZARGHAMI KHAMENEH, ALI, JAFARI, AFSHAR, NIKOOKHESLAT, SAEED, & KARIMI, POURAN. (2020). Effect of Chronic Caffeine Administration on Expression Ratio of Bax and Bcl-2 Proteins in Myocardial Tissue of Male Wistar Rats With Type 2 Diabetes. COMPLEMENTARY MEDICINE JOURNAL OF FACULTY OF NURSING & MIDWIFERY, 10(3 (36) ), 206-217. SID. https://sid.ir/paper/416132/en

Vancouver: Copy

ZARGHAMI KHAMENEH ALI, JAFARI AFSHAR, NIKOOKHESLAT SAEED, KARIMI POURAN. Effect of Chronic Caffeine Administration on Expression Ratio of Bax and Bcl-2 Proteins in Myocardial Tissue of Male Wistar Rats With Type 2 Diabetes. COMPLEMENTARY MEDICINE JOURNAL OF FACULTY OF NURSING & MIDWIFERY[Internet]. 2020;10(3 (36) ):206-217. Available from: https://sid.ir/paper/416132/en

IEEE: Copy

ALI ZARGHAMI KHAMENEH, AFSHAR JAFARI, SAEED NIKOOKHESLAT, and POURAN KARIMI, “Effect of Chronic Caffeine Administration on Expression Ratio of Bax and Bcl-2 Proteins in Myocardial Tissue of Male Wistar Rats With Type 2 Diabetes,” COMPLEMENTARY MEDICINE JOURNAL OF FACULTY OF NURSING & MIDWIFERY, vol. 10, no. 3 (36) , pp. 206–217, 2020, [Online]. Available: https://sid.ir/paper/416132/en

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