The Prevalence of H. Pylori cagA Gene in Patients with Gastric Ulcer

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KESHAVARZI FATEMEH; Mirzaei Shoaleh; KARAMI PEZHMAN

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Journal: IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY Year:2021 | Volume:15 | Issue:3 Page(s): 345-351

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Title

The Prevalence of H. Pylori cagA Gene in Patients with Gastric Ulcer

Author(s)

KESHAVARZI FATEMEH | Mirzaei Shoaleh | KARAMI PEZHMAN | Issue Writer Certificate

Keywords

CagA geneQ1

Gastric ulcerQ1

GlmM geneQ1

H.PyloriQ1

Abstract

a predisposing factor of gastric adenocarcinoma. Cytotoxin A encoded by the CagA gene is one of the major virulence factors in bacterial pathogenicity, which is of special importance due to genetic diversity in different geographical areas. The purpose of this study was to evaluate the prevalence of the CagA gene in the patients suffering from Gastric ulcers. Materials and Methods: Seventy-five paraffin blocks of stomach biopsy samples from patients infected with H. pylori and suffering from Gastric ulcers were randomly evaluated in the province of Kermanshah in the spring of 2016, Iran. DNA samples extracted by the boiling method were investigated using PCR by the use of particular primer pairs for a protected area in the GlmM gene, and the existence of the CagA gene. Results: From the 75 samples, 56 cases (%74. 66) were glmM-positive and among them, 39 cases (%69. 64) tested positive for CagA gene. Comparing patients in terms of gender, the frequency of the CagA gene was 22 (%39. 28) and 17 (%30. 35) in males and females, respectively. Finally, comparing patients in terms of age, 16 cases (%21. 33) were younger than 40 years old and 23 cases (%41. 07) were older than 40 years old. Conclusion: The results of this study showed significant association between the frequency of the CagA gene and peptic ulcer in the studied patients.

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APA: Copy

KESHAVARZI, FATEMEH, Mirzaei, Shoaleh, & KARAMI, PEZHMAN. (2021). The Prevalence of H. Pylori cagA Gene in Patients with Gastric Ulcer. IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY, 15(3 ), 345-351. SID. https://sid.ir/paper/416163/en

Vancouver: Copy

KESHAVARZI FATEMEH, Mirzaei Shoaleh, KARAMI PEZHMAN. The Prevalence of H. Pylori cagA Gene in Patients with Gastric Ulcer. IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY[Internet]. 2021;15(3 ):345-351. Available from: https://sid.ir/paper/416163/en

IEEE: Copy

FATEMEH KESHAVARZI, Shoaleh Mirzaei, and PEZHMAN KARAMI, “The Prevalence of H. Pylori cagA Gene in Patients with Gastric Ulcer,” IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY, vol. 15, no. 3 , pp. 345–351, 2021, [Online]. Available: https://sid.ir/paper/416163/en

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