Effects of Aerobic Interval Training and Adenosine on the Expression of AMPK, PPARγ and A2B Receptor in the Liver of Rats Fed a High-Fat Diet

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Hedayati katooli A.; AZARBAYEJANI M.A.; Banaeefar A.A.; ARSHADI S.

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Paper Information

Journal: JOURNAL OF ADVANCED BIOMEDICAL SCIENCES Year:2020 | Volume:10 | Issue:3 Page(s): 2655-2664

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Title

Effects of Aerobic Interval Training and Adenosine on the Expression of AMPK, PPARγ and A2B Receptor in the Liver of Rats Fed a High-Fat Diet

Author(s)

Hedayati katooli A. | AZARBAYEJANI M.A. | Banaeefar A.A. | ARSHADI S. | Issue Writer Certificate

Keywords

aerobic interval trainingQ1

adenosineQ3

high-fat dietQ1

AMPKQ1

PPARγQ1

A2BQ1

ratQ2

Abstract

Background & Objective: Obesity causes steatosis in the liver. PPARγ transcription factor of glucose and fat metabolism genes and AMPK cell energy sensor are considered as therapeutic targets in nonalcoholic fatty liver (NAFLD) patients. Despite the importance of exercise and medication in the treatment of chronic diseases, there is little agreement on the role of intense exercise (HIIT) in the treatment of NAFLD. The aim of this study was to investigate the effect of exercise intensity and adenosine on liver fat metabolism following a high-fat diet. Materials & Methods: 30 mice were randomly divided into 6 groups of 5 controls, high fat diet, high fat diet + placebo injection, high fat diet + adenosine injection, high fat diet-exercise + adenosine injection, high fat diet-exercise + placebo injection. Subjects first received 13 weeks of high-fat diet and then exercised 5 sessions per week for 12 weeks. Result: PPARγ gene expression increased in high-fat food groups (P = 0. 017), (P = 0. 007). There was no difference in AMPK expression between food groups (P = 0. 097). Exercise had a significant effect on increasing expression of AMPK, A2B (P = 0. 0001), (P = 0. 031) and a significant decrease on PPARγ (P = 0. 0001). In adenosine group, AMPK and A2B significantly increased (P = 0. 001), (P = 0. 012) and PPARγ decreased (P = 0. 0001). Simultaneous exercise and adenosine had a more significant increase in AMPK expression (P = 0. 039) and a more significant decrease in PPARγ (P = 0. 005) than the effect of each alone. Conclusion: It is possible to use high-intensity exercise with a certain amount of adenosine at the same time to prevent the accumulation of fat in the liver.

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References

Perspectives on Interval Exercise Interventions for Non-Alcoholic Fatty Liver Disease

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APA: Copy

Hedayati katooli, A., AZARBAYEJANI, M.A., Banaeefar, A.A., & ARSHADI, S.. (2020). Effects of Aerobic Interval Training and Adenosine on the Expression of AMPK, PPARγ and A2B Receptor in the Liver of Rats Fed a High-Fat Diet. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, 10(3 ), 2655-2664. SID. https://sid.ir/paper/416167/en

Vancouver: Copy

Hedayati katooli A., AZARBAYEJANI M.A., Banaeefar A.A., ARSHADI S.. Effects of Aerobic Interval Training and Adenosine on the Expression of AMPK, PPARγ and A2B Receptor in the Liver of Rats Fed a High-Fat Diet. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES[Internet]. 2020;10(3 ):2655-2664. Available from: https://sid.ir/paper/416167/en

IEEE: Copy

A. Hedayati katooli, M.A. AZARBAYEJANI, A.A. Banaeefar, and S. ARSHADI, “Effects of Aerobic Interval Training and Adenosine on the Expression of AMPK, PPARγ and A2B Receptor in the Liver of Rats Fed a High-Fat Diet,” JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, vol. 10, no. 3 , pp. 2655–2664, 2020, [Online]. Available: https://sid.ir/paper/416167/en

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