Association of Atorvastatin with Increased Growth and Quality of Immature Mouse Oocytes In-Vitro

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SADEGHI MORTEZA; SABBAGHZIARANI FATEMEH; Soleimani Pourya; Ashtarimajelan Mohammad Reza; ZAFARI FARIBA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES Year:2021 | Volume:26 | Issue:4 (114) Page(s): 30-37

Download Full-Text

Persian Verion

View:

233

Download:

Cites:

Information Journal Paper

Title

Association of Atorvastatin with Increased Growth and Quality of Immature Mouse Oocytes In-Vitro

Author(s)

Keywords

AtorvastatinQ1

OocyteQ2

MaturationQ2

InfertilityQ2

Abstract

Background and Aim: Atorvastatin is one of the medicines used for the treatment of high blood cholesterol which recently has been shown to have antioxidant effects in the cell. The aim of this study was to evaluate the effect of Atorvastatin on the growth and quality of immature mouse Oocytes in vitro. Materials and Methods: 400 Oocytes were prepared from ovaries of 40 NMRI mice and divided into two groups of control (culture medium) and Atorvastatin (culture medium + 2 μ M Atorvastatin). Then Oocyte qualitative parameters including zona pellucida thickness (ZP), Perivitelline space size (PVS) and Oocyte diameter (OD) were determined using invert microscope and image-J software. Results: Quantitative parameters of zona pellucida thickness and Oocyte diameter were increased in the Atorvastatin group compared to those in the control group. In the evaluation of Oocytes quality, the number of Oocytes exhibiting +1 score in the Atorvastatin and control groups were (70%) and (55. 4%) respectively, which showed a significant difference between the two groups (P≤ 0. 05). The numbers of polar bodies exhibiting +1 score in the Atorvastatin and control groups were (36. 18%) and (18. 5%) respectively (P≤ 0. 05). Conclusion: Use of Atorvastatin had a significant effect on the growth and final quality of the immature Oocytes in vitro and it can possibly be used to increase the efficiency of in vitro fertilization in the future.

Cites

No record.

References

No record.

Cite

APA: Copy

SADEGHI, MORTEZA, SABBAGHZIARANI, FATEMEH, Soleimani, Pourya, Ashtarimajelan, Mohammad Reza, & ZAFARI, FARIBA. (2021). Association of Atorvastatin with Increased Growth and Quality of Immature Mouse Oocytes In-Vitro. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, 26(4 (114) ), 30-37. SID. https://sid.ir/paper/416289/en

Vancouver: Copy

SADEGHI MORTEZA, SABBAGHZIARANI FATEMEH, Soleimani Pourya, Ashtarimajelan Mohammad Reza, ZAFARI FARIBA. Association of Atorvastatin with Increased Growth and Quality of Immature Mouse Oocytes In-Vitro. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2021;26(4 (114) ):30-37. Available from: https://sid.ir/paper/416289/en

IEEE: Copy

MORTEZA SADEGHI, FATEMEH SABBAGHZIARANI, Pourya Soleimani, Mohammad Reza Ashtarimajelan, and FARIBA ZAFARI, “Association of Atorvastatin with Increased Growth and Quality of Immature Mouse Oocytes In-Vitro,” SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 4 (114) , pp. 30–37, 2021, [Online]. Available: https://sid.ir/paper/416289/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops