The effect of hydro-alcoholic extract of Kelussia odoratissma Mozaffarian (KOM) seed on histopathology & joints diameter in experimental model of Incomplete Freund, s adjuvant induced arthritis in rat

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Hoseyni Lorgani S.M.; Rashidpour Aghamahali M.; KAZEMI S.; Hoseynie M.; RAFIEIAN KOPAEI M.; FEYZI F.; MOGHADAMNIA A.A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS) Year:2019 | Volume:21 | Issue:1 Page(s): 188-195

Download Full-Text

Persian Verion

View:

179

Download:

Cites:

Information Journal Paper

Title

The effect of hydro-alcoholic extract of Kelussia odoratissma Mozaffarian (KOM) seed on histopathology & joints diameter in experimental model of Incomplete Freund, s adjuvant induced arthritis in rat

Author(s)

Keywords

Kelussia odoratissma MozaffarianQ2

ArthritisQ3

InflammationQ2

Incomplete FreundQ2

s adjuvantQ2

Abstract

BACKGROUND AND OBJECTIVE: Arthritis is one of the inflammatory diseases that can cause debilitating problems. Existing drugs have numerous side effects that limit their use. KOM has anti-inflammatory properties due to its flavonoid compounds. Therefore, this study was performed to investigate the anti-inflammatory effects of hydroalcoholic extract of KOM in an experimental model of Arthritis. METHODS: In this experimental study, 46 male Wistar rats were randomly divided into 7 groups: healthy and patient control groups, normal saline recipient, hydrocortisone recipient and 3 groups treated with hydroalcoholic extract at doses of 300, 500 and 700 mg/kg. First, KOM was extracted then Arthritis induced by injection of 0. 1 cc of Incomplete Freund's adjuvant, and from 15th day KOM extract was injected intraperitoneally. On the last day (31st), their ankle joint was prepared for histological examination and the groups were compared. FINDINGS: The results showed that doses of 300, 500 and 700 mg/kg of hydroalcoholic extract did not significantly reduce joint diameter. Histologic studies of positive control group showed subcutaneous Inflammation, destruction and fibrosis of cartilage and panus formation which subcutaneous Inflammation was reduced in the low and high doses of the extract (p<0. 05). CONCLUSION: The results of this study showed that hydroalcoholic extract of KOM reduced subcutaneous Inflammation but had no significant effect on joint diameter and other histopathologic and immunological changes in IFA induced Arthritis.

Cites

No record.

References

No record.

Cite

APA: Copy

Hoseyni Lorgani, S.M., Rashidpour Aghamahali, M., KAZEMI, S., Hoseynie, M., RAFIEIAN KOPAEI, M., FEYZI, F., & MOGHADAMNIA, A.A.. (2019). The effect of hydro-alcoholic extract of Kelussia odoratissma Mozaffarian (KOM) seed on histopathology & joints diameter in experimental model of Incomplete Freund, s adjuvant induced arthritis in rat. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), 21(1 ), 188-195. SID. https://sid.ir/paper/416320/en

Vancouver: Copy

Hoseyni Lorgani S.M., Rashidpour Aghamahali M., KAZEMI S., Hoseynie M., RAFIEIAN KOPAEI M., FEYZI F., MOGHADAMNIA A.A.. The effect of hydro-alcoholic extract of Kelussia odoratissma Mozaffarian (KOM) seed on histopathology & joints diameter in experimental model of Incomplete Freund, s adjuvant induced arthritis in rat. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS)[Internet]. 2019;21(1 ):188-195. Available from: https://sid.ir/paper/416320/en

IEEE: Copy

S.M. Hoseyni Lorgani, M. Rashidpour Aghamahali, S. KAZEMI, M. Hoseynie, M. RAFIEIAN KOPAEI, F. FEYZI, and A.A. MOGHADAMNIA, “The effect of hydro-alcoholic extract of Kelussia odoratissma Mozaffarian (KOM) seed on histopathology & joints diameter in experimental model of Incomplete Freund, s adjuvant induced arthritis in rat,” JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), vol. 21, no. 1 , pp. 188–195, 2019, [Online]. Available: https://sid.ir/paper/416320/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops