The effect of high-intensity interval training on the expression of protein kinase B (Akt gene) in the left ventricle of male rats with type 2 diabetes

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Moeini Masoud; BEHPOOR NASER; TADIBI VAHID

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Journal: Journal of Jiroft University of Medical Sciences Year:2020 | Volume:7 | Issue:2 Page(s): 332-340

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Title

The effect of high-intensity interval training on the expression of protein kinase B (Akt gene) in the left ventricle of male rats with type 2 diabetes

Author(s)

Moeini Masoud | BEHPOOR NASER | TADIBI VAHID | Issue Writer Certificate

Keywords

high intensity interval training

AKT gene expression

Type 2 diabetes

Insulin Resistance

Abstract

Introduction: The term diabetes heart in diabetic patients includes pathologic left ventricular hypertrophy. Stimulation of the signaling and molecular pathways of cardiac myocardial remodeling through exercise inthis regard can be considered as a therapeutic strategy for physiological development of the left ventricle. In the present study, the effect of 8 weeks of high intensity interval training on protein kinase B (AKT)gene expression, Insulin Resistance level, heart weight, glucose and serum insulin in male Wistar rats withType 2 diabetes. Materials and Methods: Twenty male wistar rats, 10 weeks old, weighing 220± 20gr were randomlydivided into two groups: HIIT group and control group. After familiarization, the training groupparticipated in an 8-week protocol, 5 sessions per week, for 30 minutes per session. To check the AKTgene expression and the variables serum levels, RT-PCR method and ELISA method were used. The data were analyzed by t-test for independent groups at p<0. 05 level Results: It was observed that in the HIIT group, AKT expression was significantly higher than that of the control group (p<0. 01). Exercise also significantly decreased Insulin Resistance (p<0. 001) and serumglucose index (p<0. 001), while serum insulin increased significantly (p<0. 05) in association with thisdecrease. Rats weight in the training group also increased compared to the control group (p<0. 05). Conclusion: HIIT exercise increases the expression of AKT gene, stimulates the physiological molecularpathway of hypertrophy and plays a role in preventing left ventricular hypertrophy as a complementarytreatment.

Cites

The Effect of Protein Kinase-B on FOXO Autophagy Family Proteins (FOXO1 and FOXO3a) Following High Intensity Interval Training in the Left Ventricle of the Heart of Diabetic Rats by Streptozotocin and Nicotinamide

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APA: Copy

Moeini, Masoud, BEHPOOR, NASER, & TADIBI, VAHID. (2020). The effect of high-intensity interval training on the expression of protein kinase B (Akt gene) in the left ventricle of male rats with type 2 diabetes. JOURNAL OF JIROFT UNIVERSITY OF MEDICAL SCIENCES, 7(2 ), 332-340. SID. https://sid.ir/paper/416384/en

Vancouver: Copy

Moeini Masoud, BEHPOOR NASER, TADIBI VAHID. The effect of high-intensity interval training on the expression of protein kinase B (Akt gene) in the left ventricle of male rats with type 2 diabetes. JOURNAL OF JIROFT UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;7(2 ):332-340. Available from: https://sid.ir/paper/416384/en

IEEE: Copy

Masoud Moeini, NASER BEHPOOR, and VAHID TADIBI, “The effect of high-intensity interval training on the expression of protein kinase B (Akt gene) in the left ventricle of male rats with type 2 diabetes,” JOURNAL OF JIROFT UNIVERSITY OF MEDICAL SCIENCES, vol. 7, no. 2 , pp. 332–340, 2020, [Online]. Available: https://sid.ir/paper/416384/en

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