Prevalence of blaZ in Clinical Isolates of Staphylococcus aureus Isolated from Hamedan Hospitals

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Kakaei Romina; Momen Amir Hossein; Vazini Hossein

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Journal Paper

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Journal: Journal of Neyshabur University of Medical Sciences Year:2020 | Volume:8 | Issue:3 (28) Page(s): 48-58

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Information Journal Paper

Title

Prevalence of blaZ in Clinical Isolates of Staphylococcus aureus Isolated from Hamedan Hospitals

Author(s)

Kakaei Romina | Momen Amir Hossein | Vazini Hossein | Issue Writer Certificate

Keywords

Gene blaZQ1

StaphylococcusQ2

Clinical IsolateQ2

Drug resistanceQ2

Abstract

Introduction: Staphylococcus aureus (S. aureus) has been recognized as a powerful pathogen that causes numerous infections. Today, S. aureus has acquired multiple resistance to a wide range of antibiotics, including beta-lactams. Betalactamases hydrolyze beta-lactam antibiotics and are expressed through activation of the blaZ gene. The aim of this study was to evaluate the frequency of blaZ gene in Clinical Isolates of S. aureus isolated from Hamadan hospitals. Materials and Methods: In this descriptive cross-sectional study, all S. aureus strains were randomly selected and transferred to the laboratory. In Clinical Isolates confirmed by biochemical tests of genomic DNA extraction procedures using CinnaGen extraction kit) was performed according to the manufacturer's protocol and 1% agarose gel was used to view the PCR product. Data were analyzed by SPSS software. Results: From 50 hospitalized patients in Fatemieh and Sina hospitals, 32 men (64%), and 18 women (36%), isolates of S. aureus were isolated. The pattern of antibiotic resistance obtained was that penicillin (10 μ g) with 100% resistance and cefazolin (30 μ g) with 5% resistance had the highest and lowest resistance, respectively. Also, 94% of isolates were resistant to cefoxitin (30 μ g) and 90% of isolates were resistant to oxacillin (1 μ g). Of 50 S. aureus isolated from Clinical Isolates, 44 (88 %) contained the blaZ beta-lactamase gene. Conclusion: Based on the findings of this study, isolates isolated from clinical specimens showed the same pattern of abundance. Therefore, it is likely that more or more Drug resistance will be transmitted to hospitals.

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APA: Copy

Kakaei, Romina, Momen, Amir Hossein, & Vazini, Hossein. (2020). Prevalence of blaZ in Clinical Isolates of Staphylococcus aureus Isolated from Hamedan Hospitals. JOURNAL OF NEYSHABUR UNIVERSITY OF MEDICAL SCIENCES, 8(3 (28) ), 48-58. SID. https://sid.ir/paper/416499/en

Vancouver: Copy

Kakaei Romina, Momen Amir Hossein, Vazini Hossein. Prevalence of blaZ in Clinical Isolates of Staphylococcus aureus Isolated from Hamedan Hospitals. JOURNAL OF NEYSHABUR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;8(3 (28) ):48-58. Available from: https://sid.ir/paper/416499/en

IEEE: Copy

Romina Kakaei, Amir Hossein Momen, and Hossein Vazini, “Prevalence of blaZ in Clinical Isolates of Staphylococcus aureus Isolated from Hamedan Hospitals,” JOURNAL OF NEYSHABUR UNIVERSITY OF MEDICAL SCIENCES, vol. 8, no. 3 (28) , pp. 48–58, 2020, [Online]. Available: https://sid.ir/paper/416499/en

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