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Information Journal Paper

Title

SURVEY OF DRUG RESISTANCE DUE TO EXTENDED SPECTRUM BETA-IACTAMASES IN KLEBSIELLA PNEUMONIAE STRAINS ISOLATED FROM HOSPITALIZED PATIENTS

Pages

  241-245

Keywords

EXTENDED SPECTRUM BETA-LACTAMASE (ESRL)Q2
MULTIPLE DRUG RESISTANCE (MDR)Q3

Abstract

 Background: KLEBSIELLA PNEUMONIAE is one of the most important and prevalent bacterium isolated from clinical cases especially from hospitalized patients. Recent studies have focused on multiple drug resistant Kpneumoniae strains. In this survey, drug resistance in clinical isolates was studied with special reference to extended spectrum b-lactamase.Methods: A total of 303 Kpneumoniae strains isolated from hospitalized patients were initially surveyed for drug resistance by disc diffusion method. The resistance of the isolated strains to different antibiotics was determined by E-test. b-lactamase production was tested with nitrocephin discs and extended spectrum b-lactamase assays were performed with double disc synergy tests. Results: From the total of 303 Kpneumoniae isolates tested, 62, (20.4%), showed multi drug resistance, (MDR). All of these MDR strains were positive for nitrocephin test, indicating b-lactamase production. Double disc synergy tests results showed production of extended spectrum b-lactamase in all MDR isolates.Conclusion: Detection of 20.4% MDR strains, especially extended spectrum b-lactamase, from K.pneumoniae isolated from hospitalized patients, emphasizes the potential dangers of the widespread usage of extended spectrum cephalosporins. It also necessitates conduction of a wider study to determine the nationwide incidence of K. pneumoniae.

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    APA: Copy

    AMIR MOZAFARI, N., TEHRANI, H.F., TAVAF LANGEROUDI, Z., & ABD ELAHI, ABAS. (2007). SURVEY OF DRUG RESISTANCE DUE TO EXTENDED SPECTRUM BETA-IACTAMASES IN KLEBSIELLA PNEUMONIAE STRAINS ISOLATED FROM HOSPITALIZED PATIENTS. PAJOUHESH DAR PEZESHKI, 31(3), 241-245. SID. https://sid.ir/paper/41765/en

    Vancouver: Copy

    AMIR MOZAFARI N., TEHRANI H.F., TAVAF LANGEROUDI Z., ABD ELAHI ABAS. SURVEY OF DRUG RESISTANCE DUE TO EXTENDED SPECTRUM BETA-IACTAMASES IN KLEBSIELLA PNEUMONIAE STRAINS ISOLATED FROM HOSPITALIZED PATIENTS. PAJOUHESH DAR PEZESHKI[Internet]. 2007;31(3):241-245. Available from: https://sid.ir/paper/41765/en

    IEEE: Copy

    N. AMIR MOZAFARI, H.F. TEHRANI, Z. TAVAF LANGEROUDI, and ABAS ABD ELAHI, “SURVEY OF DRUG RESISTANCE DUE TO EXTENDED SPECTRUM BETA-IACTAMASES IN KLEBSIELLA PNEUMONIAE STRAINS ISOLATED FROM HOSPITALIZED PATIENTS,” PAJOUHESH DAR PEZESHKI, vol. 31, no. 3, pp. 241–245, 2007, [Online]. Available: https://sid.ir/paper/41765/en

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