THE EFFECT OF MS14 ON BODY WEIGHT, SPLEEN INDEX AND STRUCTURES OF KIDNEY, LIVER, SPLEEN, LUNG, LYMPH NODE AND BONE MARROW HISTOLOGY IN BALB/C MICE

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SEDAGHAT REZA; YARAEE ROYA; NASERI MOHSEN; NAGHIZADEH MOHAMMAD MEHDI

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Journal: Research in Medicine Year:2010 | Volume:34 | Issue:1 Page(s): 8-12

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Title

THE EFFECT OF MS14 ON BODY WEIGHT, SPLEEN INDEX AND STRUCTURES OF KIDNEY, LIVER, SPLEEN, LUNG, LYMPH NODE AND BONE MARROW HISTOLOGY IN BALB/C MICE

Author(s)

SEDAGHAT REZA | YARAEE ROYA | NASERI MOHSEN | NAGHIZADEH MOHAMMAD MEHDI | Issue Writer Certificate

Keywords

MS14Q2

"BODY WEIGHT"Q3

SPLEEN INDEXQ2

SPLEENQ3

LYMPH NODESQ2

HISTOLOGYQ3

Abstract

Background: MS14 is an Herbal-marine preparation that has been used in experimental studies for the management of Multiple sclerosis, (MS). In this study the effect of MS14 on body weight, SPLEEN INDEX/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank"> SPLEEN INDEX and the histological picture of various organs was evaluated.Methods: Female Balb/C mice of 6-8 weeks age were divided into control and test groups. MS14 was orally administrated at a dose of 100 mg/kg for five days to the experimental group and normal saline given to the control group. After euthanasia on day six, the body weight was measured, SPLEEN INDEX/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank"> SPLEEN INDEX was calculated and representative pieces of tissues including kidney, liver, SPLEEN, lung, lymph node and bone marrow were collected in 10% formalin solution and processed through a standard paraffin embedding method. Sections of 5 micrometer thickness were cut and stained with hematoxylin and eosin.Results: MS14 at 100 mg/kg did not affect body weight and SPLEEN INDEX/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank"> SPLEEN INDEX, but in the test group, at least 50% of SPLEEN and 90% of lymph node micro sections showed lymphoid hyperplasia: no reactive changes were observed in controls. In both groups, histological evaluation of kidney, liver, SPLEEN, lung, lymph node and bone marrow micro sections showed no significant histological alterations in the normal architecture.Conclusion: According to result of this study, it seems that although MS14 has no effect on body weight and SPLEEN INDEX/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank"> SPLEEN INDEX, it may induce hyperplastic changes in SPLEEN & LYMPH NODES, thus signaling activation of the immune system.

Cites

THE EFFECT OF MS14 ON PRODUCTION OF PRO-INFLAMMATORY CYTOKINES BY MACROPHAGES

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APA: Copy

SEDAGHAT, REZA, YARAEE, ROYA, NASERI, MOHSEN, & NAGHIZADEH, MOHAMMAD MEHDI. (2010). THE EFFECT OF MS14 ON BODY WEIGHT, SPLEEN INDEX AND STRUCTURES OF KIDNEY, LIVER, SPLEEN, LUNG, LYMPH NODE AND BONE MARROW HISTOLOGY IN BALB/C MICE. PAJOUHESH DAR PEZESHKI, 34(1), 8-12. SID. https://sid.ir/paper/41904/en

Vancouver: Copy

SEDAGHAT REZA, YARAEE ROYA, NASERI MOHSEN, NAGHIZADEH MOHAMMAD MEHDI. THE EFFECT OF MS14 ON BODY WEIGHT, SPLEEN INDEX AND STRUCTURES OF KIDNEY, LIVER, SPLEEN, LUNG, LYMPH NODE AND BONE MARROW HISTOLOGY IN BALB/C MICE. PAJOUHESH DAR PEZESHKI[Internet]. 2010;34(1):8-12. Available from: https://sid.ir/paper/41904/en

IEEE: Copy

REZA SEDAGHAT, ROYA YARAEE, MOHSEN NASERI, and MOHAMMAD MEHDI NAGHIZADEH, “THE EFFECT OF MS14 ON BODY WEIGHT, SPLEEN INDEX AND STRUCTURES OF KIDNEY, LIVER, SPLEEN, LUNG, LYMPH NODE AND BONE MARROW HISTOLOGY IN BALB/C MICE,” PAJOUHESH DAR PEZESHKI, vol. 34, no. 1, pp. 8–12, 2010, [Online]. Available: https://sid.ir/paper/41904/en

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