EVALUATION OF FACTORS EFFECTIVE IN CLINICAL RESPONSE OF PATIENTS WITH RELAPSING REMITTING MULTIPLE SCLEROSIS TO INTERFERON BETA 1A

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BALADI MOGHADDAM NAHID; BAKHSHANDEH MOGHADDAM ISA; BAGHIZADEH SOMAYYEH

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Journal: Research in Medicine Year:2010 | Volume:34 | Issue:4 Page(s): 239-243

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Title

EVALUATION OF FACTORS EFFECTIVE IN CLINICAL RESPONSE OF PATIENTS WITH RELAPSING REMITTING MULTIPLE SCLEROSIS TO INTERFERON BETA 1A

Author(s)

BALADI MOGHADDAM NAHID | BAKHSHANDEH MOGHADDAM ISA | BAGHIZADEH SOMAYYEH | Issue Writer Certificate

Keywords

RELAPSING REMITTING MULTIPLE SCLEROSISQ3

EXPANDED DISABILITY STATUS SCORE (EDSS)Q3

INTERFERON BETA 1AQ3

Abstract

Background: Intramuscular injection of INTERFERON BETA 1A (IFN-b1a), is used for treatment of RELAPSING REMITTING MULTIPLE SCLEROSIS (RRMS); however unknown demographic and clinical factors result in an unpredictable therapeutic response. This study was conducted to evaluate the clinical response of RRMS patients referred to Imam Hossein hospital to IFN-b1a between 2005 and 2006.Methods: This clinical trial with before and after design was performed on 63 patients. Diagnosis was based on revised McDonald criteria 2005. Basal patients’ characteristics, including early manifestations, episodes of attacks, interval between the beginning of disease and induction of treatment, and expanded disability status score (EDSS) were gathered. IFN-b1a (Biogen Company) was administered intramuscularly in a dose of 30 microgram per week for 18 months. After completion of treatment, EDSS scores and episodes of attacks were evaluatedOccurrence of less than two attacks and decreased or unchanged EDSS score within 18 months were considered as a satisfactory response to treatment. Statistical analysis was done by McNemar, Mann Whitney U, chi-square and t test.Results: Out of 63 patients between ages of 18-50 years, 30 (47.6%) were had a satisfactory response. Patients’ age has no effects on treatment response. Female sex, lower interval between early manifestation and beginning of treatment, fewer episodes and lower EDSS before treatment had positive effects on therapeutic response.Conclusion: It seems that IFN-b1a is effective in the treatment of RRMS patients, lower interval between early manifestation and beginning of treatment, lower episodes of attacks and lower EDSS before treatment.

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APA: Copy

BALADI MOGHADDAM, NAHID, BAKHSHANDEH MOGHADDAM, ISA, & BAGHIZADEH, SOMAYYEH. (2010). EVALUATION OF FACTORS EFFECTIVE IN CLINICAL RESPONSE OF PATIENTS WITH RELAPSING REMITTING MULTIPLE SCLEROSIS TO INTERFERON BETA 1A. PAJOUHESH DAR PEZESHKI, 34(4), 239-243. SID. https://sid.ir/paper/41919/en

Vancouver: Copy

BALADI MOGHADDAM NAHID, BAKHSHANDEH MOGHADDAM ISA, BAGHIZADEH SOMAYYEH. EVALUATION OF FACTORS EFFECTIVE IN CLINICAL RESPONSE OF PATIENTS WITH RELAPSING REMITTING MULTIPLE SCLEROSIS TO INTERFERON BETA 1A. PAJOUHESH DAR PEZESHKI[Internet]. 2010;34(4):239-243. Available from: https://sid.ir/paper/41919/en

IEEE: Copy

NAHID BALADI MOGHADDAM, ISA BAKHSHANDEH MOGHADDAM, and SOMAYYEH BAGHIZADEH, “EVALUATION OF FACTORS EFFECTIVE IN CLINICAL RESPONSE OF PATIENTS WITH RELAPSING REMITTING MULTIPLE SCLEROSIS TO INTERFERON BETA 1A,” PAJOUHESH DAR PEZESHKI, vol. 34, no. 4, pp. 239–243, 2010, [Online]. Available: https://sid.ir/paper/41919/en

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