SURVEYING THE PROPHYLACTIC EFFECTS OF INTRAVENOUS SINGLE DOSE OF CEFALOTIN IN CLEAN HEAD AND NECK SURGERY

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KHAJAVI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Research in Medicine Year:2001 | Volume:25 | Issue:2 Page(s): 31-35

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Title

SURVEYING THE PROPHYLACTIC EFFECTS OF INTRAVENOUS SINGLE DOSE OF CEFALOTIN IN CLEAN HEAD AND NECK SURGERY

Author(s)

KHAJAVI M. | Issue Writer Certificate

Keywords

CEFALOTINQ4

PROPHYLAXIS AGAINST INFECTION IN SURGERYQ4

Abstract

Background: Regarding the widely usage of antibiotics as prophylactic agents against infections followed by operations, this study has been carried out to determine the prophylactic effects of intravenous single dose of CEFALOTIN, in comparison with the common regimen of the same antibiotic for one week, in clean (non-infected and those not related to air ways or GI tract) head and neck surgery in ENT ward, Loghman Hakim hospital, 1996-97. Materials and methods: This clinical trial of double-blinded and sequential type was achieved on 124 patients aged 6-72 years old. Patients were distributed in two groups of case and control. Case group was received a single dose of CEFALOTIN intravenously (25mg/kg) 30 minutes before the operation, then received placebo every 6 hours (QID) for a week. In the control group the same pre-operation regimen was observed, however, intravenous CEFALOTIN was given at the dose of 12.5 mg/kg every 6 hours for a week. Patients were examined at the Ist,2nd, and 3rd week. Results: 62 patients were put in each group. Post-operation infection incidence was 6.5% (4 cases) and 4.8%(3 cases) in the case and control group, respectively, where the difference is not statistically significant. Conclusion: Concerning our results and also other similar studies, single dose of intravenous CEFALOTIN revealed to be an effective prophylactic agent in clean operations and could be a suitable alternative for routine regimens. Further studies to determine the efficacy of this approach for clean-contaminated and/or infected operations are highly recommended.

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APA: Copy

KHAJAVI, M.. (2001). SURVEYING THE PROPHYLACTIC EFFECTS OF INTRAVENOUS SINGLE DOSE OF CEFALOTIN IN CLEAN HEAD AND NECK SURGERY. PAJOUHESH DAR PEZESHKI, 25(2), 31-35. SID. https://sid.ir/paper/41930/en

Vancouver: Copy

KHAJAVI M.. SURVEYING THE PROPHYLACTIC EFFECTS OF INTRAVENOUS SINGLE DOSE OF CEFALOTIN IN CLEAN HEAD AND NECK SURGERY. PAJOUHESH DAR PEZESHKI[Internet]. 2001;25(2):31-35. Available from: https://sid.ir/paper/41930/en

IEEE: Copy

M. KHAJAVI, “SURVEYING THE PROPHYLACTIC EFFECTS OF INTRAVENOUS SINGLE DOSE OF CEFALOTIN IN CLEAN HEAD AND NECK SURGERY,” PAJOUHESH DAR PEZESHKI, vol. 25, no. 2, pp. 31–35, 2001, [Online]. Available: https://sid.ir/paper/41930/en

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