IGG4 CHARACTERISTICS AND IGG4 RELATED DISEASES

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YOUSEFI ROYA; AMANI DAVAR

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Research in Medicine Year:2018 | Volume:41 | Issue:4 Page(s): 294-307

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Information Journal Paper

Title

IGG4 CHARACTERISTICS AND IGG4 RELATED DISEASES

Author(s)

YOUSEFI ROYA | AMANI DAVAR | Issue Writer Certificate

Keywords

IGG4Q1

IGG4 RELATED DISEASEQ1

IGG4-RDQ1

Abstract

Background: In the serum of healthy people, IGG4 has the lowest concentration among the different subclasses of IgG. Elevation of serum IGG4 in response to chronic antigenic stimulation and inflammation has been reported. Inflammation, histopathologic lesions, and systemic organ involvement have been reported in the IGG4-related disease (IGG4-RD). In this article, we review IGG4 unique features and its role in the immunopathogenesis of IGG4RD, a new class of human disease. In this article, we emphasize on the potential role of IGG4 for the treatment in tumor immunity. Materials and Methods: We systematically searched the Pub Med, Google Scholar, Scopus and Science Direct databases with IGG4, IGG4 related disease and IGG4-RD keywords .Finally, Seventy-four English-language articles reporting IGG4 and IGG4 RD were included.Conclusion: IGG4-RD is classified as rare diseases and to date, the exact prevalence of it has not been reported. In recent years the disease features have been described, but a long way is ahead of scientists to understand of IGG4RD mechanisms. The role of humoral (antibody) immune response against tumor antigens is the main interest of scientists. Histological studies in some tumors such as melanoma show the presence of anti-tumor antibodies within inflammatory tumor lesions. Unique biological property of IGG4, such as the ability to switch Fab arms, results in inhibition of immune complex formation and ineffective antibody dependent cell killing. IGG4 as blocking antibody has a protective role in allergy by inhibiting the release of mast cells granules. Also in malignant melanoma, IGG4 suppresses antitumor immune response via inhibition of IgG1 binding to tumor cells. These findings emphasize that new investigations are necessary for understanding the importance of IGG4 in health and diseases.

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APA: Copy

YOUSEFI, ROYA, & AMANI, DAVAR. (2018). IGG4 CHARACTERISTICS AND IGG4 RELATED DISEASES. PAJOUHESH DAR PEZESHKI, 41(4 ), 294-307. SID. https://sid.ir/paper/41941/en

Vancouver: Copy

YOUSEFI ROYA, AMANI DAVAR. IGG4 CHARACTERISTICS AND IGG4 RELATED DISEASES. PAJOUHESH DAR PEZESHKI[Internet]. 2018;41(4 ):294-307. Available from: https://sid.ir/paper/41941/en

IEEE: Copy

ROYA YOUSEFI, and DAVAR AMANI, “IGG4 CHARACTERISTICS AND IGG4 RELATED DISEASES,” PAJOUHESH DAR PEZESHKI, vol. 41, no. 4 , pp. 294–307, 2018, [Online]. Available: https://sid.ir/paper/41941/en

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