INVESTIGATION OF CORRELATION BETWEEN -765G/C POLYMORPHISM OF CYCLOOXYGENASE 2 GENES AND LUNG CANCER IN ISFAHAN POPULATION

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MOTOVALI BASHI MAJID; HOJATI ZOHREH; ASKARY MALSHAIKH MASOUD

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Journal: Research in Medicine Year:2013 | Volume:37 | Issue:1 Page(s): 47-54

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Title

INVESTIGATION OF CORRELATION BETWEEN -765G/C POLYMORPHISM OF CYCLOOXYGENASE 2 GENES AND LUNG CANCER IN ISFAHAN POPULATION

Author(s)

MOTOVALI BASHI MAJID | HOJATI ZOHREH | ASKARY MALSHAIKH MASOUD | Issue Writer Certificate

Keywords

CYCLOOXYGENASESQ2

PROSTAGLANDINQ2

METASTATIC ACTIVITYQ2

LUNG CANCERQ2

Abstract

Background: Two types of Cyclooxygenase enzymes, which produce PROSTAGLANDINs, are present in humans. PROSTAGLANDINs play a role in the functions of various organs including the immune system, blood circulation, and cell division. Reports indicate that the level of these enzymes is increased in patients with metastases in several malignancies, including larynx, lung, stomach, colon, and prostate. The aim of this study was to investigate the association between -765 G/C promoter polymorphism of cyclooxygenase 2 and initiation and progression of LUNG CANCER.Materials and methods: This is a case-control, retrospective study. Genotyping of CYCLOOXYGENASES was carried out by testing blood samples from 120 LUNG CANCER patients and 110 controls using restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) technique. The observed numbers of each cyclooxygenase genotype were compared with that expected for a population in Hardy-Weinberg equilibrium by using a χ2 test. The significance of the differences of observed alleles and genotypes between groups was tested using the odds ratio analysis. Results: The genotype GG of polymorphism -765G/C seen in 62.5% of patients did not indicate a significant statistic increase in comparison with the control group (55.45%; P<0.6); however, when the patients were divided into two groups i.e. those with metastases and without metastases, a weak link was identified between genotype GG of polymorphism G/C, with metastasizing cancer, (P<0.04). Dividing patients into sub-groups such as sex and smoking habit showed no difference.Conclusion: It seems that there is no association between -765 G/C polymorphism and developing of LUNG CANCER statistically. But genotype GG of polymorphism -765G/C is linked weakly with LUNG CANCER metastases.

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APA: Copy

MOTOVALI BASHI, MAJID, HOJATI, ZOHREH, & ASKARY MALSHAIKH, MASOUD. (2013). INVESTIGATION OF CORRELATION BETWEEN -765G/C POLYMORPHISM OF CYCLOOXYGENASE 2 GENES AND LUNG CANCER IN ISFAHAN POPULATION. PAJOUHESH DAR PEZESHKI, 37(1), 47-54. SID. https://sid.ir/paper/42052/en

Vancouver: Copy

MOTOVALI BASHI MAJID, HOJATI ZOHREH, ASKARY MALSHAIKH MASOUD. INVESTIGATION OF CORRELATION BETWEEN -765G/C POLYMORPHISM OF CYCLOOXYGENASE 2 GENES AND LUNG CANCER IN ISFAHAN POPULATION. PAJOUHESH DAR PEZESHKI[Internet]. 2013;37(1):47-54. Available from: https://sid.ir/paper/42052/en

IEEE: Copy

MAJID MOTOVALI BASHI, ZOHREH HOJATI, and MASOUD ASKARY MALSHAIKH, “INVESTIGATION OF CORRELATION BETWEEN -765G/C POLYMORPHISM OF CYCLOOXYGENASE 2 GENES AND LUNG CANCER IN ISFAHAN POPULATION,” PAJOUHESH DAR PEZESHKI, vol. 37, no. 1, pp. 47–54, 2013, [Online]. Available: https://sid.ir/paper/42052/en

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