EVALUATION OF THE RESULTS OF LYMPHOCYTE TRANSFORMATION TEST IN PATIENTS WITH HYPERSENSITIVITY REACTIONS FOLLOWING PHENYTOIN USAGE AND CONTROL GROUP

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KARAMI ZAHRA; MESDAGHI MEHRNAZ; CHAVOSHZADEH ZAHRA; KARIMZADEH PARVANEH; MANSOURI MAHBOUBEH; SHEKARRIZ REZA

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Journal: Research in Medicine Year:2015 | Volume:39 | Issue:2 Page(s): 87-91

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Title

EVALUATION OF THE RESULTS OF LYMPHOCYTE TRANSFORMATION TEST IN PATIENTS WITH HYPERSENSITIVITY REACTIONS FOLLOWING PHENYTOIN USAGE AND CONTROL GROUP

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LTT CAN BE A HELPFUL METHOD IN DIAGNOSIS OF THE DRUG THAT HAS CAUSED HYPERSENSITIVITY REACTIONQ2

Abstract

Background: Administration of phenytoin can been associated with severe adverse reactions such as hypersensitivity reactions. Lymphocyte transformation test (LTT) can be a useful method for determination of the drug, which has caused hypersensitivity reaction. This study was done to evaluate the results of lymphocyte transformation test in patients with delayed hypersensitivity reactions following phenytoin administration and control group.Methods: In a case-control study, four patients with hypersensitivity reactions following administration of phenytoin and ten patients, who had used phenytoin without hypersensitivity reactions, were included. Peripheral blood mononuclear cells were isolated. The cells were stimulated with Phenytoin, PHA (Phytohaemagglutinin) as a mitogen and candida as an antigen. Lymphocyte proliferation was measured using Brdu proliferation assay kit (Roche, Germany). The stimulation index was calculated by dividing OD of stimulated to unstimulated cells.Stimulation index more than 2 was considered as positive. The results in case and control groups were compared, using Fisher’s exact test.Results: Out of 4 patients in the test group, 3 had positive LTT results and one had negative test result. Among patients in control group, none of them had positive LTT result. This difference was statistically significant (p=0.002). The mean time between development of drug reactions and perform the LTT was 16±6.9 months in the test group with positive result and 38 months in test group with negative test result. This difference was not statistically significant (p=0.174).

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APA: Copy

KARAMI, ZAHRA, MESDAGHI, MEHRNAZ, CHAVOSHZADEH, ZAHRA, KARIMZADEH, PARVANEH, MANSOURI, MAHBOUBEH, & SHEKARRIZ, REZA. (2015). EVALUATION OF THE RESULTS OF LYMPHOCYTE TRANSFORMATION TEST IN PATIENTS WITH HYPERSENSITIVITY REACTIONS FOLLOWING PHENYTOIN USAGE AND CONTROL GROUP. PAJOUHESH DAR PEZESHKI, 39(2), 87-91. SID. https://sid.ir/paper/42098/en

Vancouver: Copy

KARAMI ZAHRA, MESDAGHI MEHRNAZ, CHAVOSHZADEH ZAHRA, KARIMZADEH PARVANEH, MANSOURI MAHBOUBEH, SHEKARRIZ REZA. EVALUATION OF THE RESULTS OF LYMPHOCYTE TRANSFORMATION TEST IN PATIENTS WITH HYPERSENSITIVITY REACTIONS FOLLOWING PHENYTOIN USAGE AND CONTROL GROUP. PAJOUHESH DAR PEZESHKI[Internet]. 2015;39(2):87-91. Available from: https://sid.ir/paper/42098/en

IEEE: Copy

ZAHRA KARAMI, MEHRNAZ MESDAGHI, ZAHRA CHAVOSHZADEH, PARVANEH KARIMZADEH, MAHBOUBEH MANSOURI, and REZA SHEKARRIZ, “EVALUATION OF THE RESULTS OF LYMPHOCYTE TRANSFORMATION TEST IN PATIENTS WITH HYPERSENSITIVITY REACTIONS FOLLOWING PHENYTOIN USAGE AND CONTROL GROUP,” PAJOUHESH DAR PEZESHKI, vol. 39, no. 2, pp. 87–91, 2015, [Online]. Available: https://sid.ir/paper/42098/en

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