REGIONAL DIFFERENCES IN THE ROLE OF HYPERPOLARIZATION-ACTIVATED CURRENT 'IF' IN PACEMAKER POTENTIAL WITHIN THE INTACT SINOATRIAL NODE OF THE HEART IN RABBIT

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NIKMARAM M.R.; RICHARD BOYETT M.

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Journal: Research in Medicine Year:2003 | Volume:27 | Issue:2 Page(s): 103-111

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Title

REGIONAL DIFFERENCES IN THE ROLE OF HYPERPOLARIZATION-ACTIVATED CURRENT 'IF' IN PACEMAKER POTENTIAL WITHIN THE INTACT SINOATRIAL NODE OF THE HEART IN RABBIT

Author(s)

NIKMARAM M.R. | RICHARD BOYETT M. | Issue Writer Certificate

Keywords

SINOATRIAL NODEQ4

'IF' IONIC CURRENTQ4

REGIONAL DIFFERENCESQ4

Abstract

Background: The sinoatrial (SA) node is not a uniform tissue in terms of its histology and electrophysiology.The REGIONAL DIFFERENCES in action potential configuration are well known, for which the difference on ionic currents underlying the REGIONAL DIFFERENCES in electrical activity is the most probable cause. The ionic current 'if’ is thought to play a major role in SA node for pace maker slope of action potential.Materials and methods: This predication was tested in the present study by block of the current on pacemaker activity in the periphery and center of the intact SA node of the rabbit heart by means of 2mM Cs+ for 20 min.First, the action potential of different regions of SA node was recorded by conventional glass microelectrode without Cs+ and nine criteria of action potential configuration were measured. Then, Cs+ was used and again criteria were measured.Results: In all cases, Cs+ significantly decreased the pacemaker slope (PS) from 20±1 (control) to 4±1 mVis (n=8) in peripheral zone, from 32±4 (control) to 17±2 mV/s (n=7) in transitional zone and from 49±3 (control) to 36±4 mV/s (n=6) in central zone. Meanwhile, 2mM Cs+ also decreased the rate of spontaneous activity by 12±1%.Instead of rate, the cycle length (CL) was recorded, where the increment on cycle length was reported to be 14±1%.Conclusion: ‘if’ current plays a major role in the pacemaker activities in central zone rather than the peripheral zone of intact SA node of the rabbit heart.

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APA: Copy

NIKMARAM, M.R., & RICHARD BOYETT, M.. (2003). REGIONAL DIFFERENCES IN THE ROLE OF HYPERPOLARIZATION-ACTIVATED CURRENT 'IF' IN PACEMAKER POTENTIAL WITHIN THE INTACT SINOATRIAL NODE OF THE HEART IN RABBIT. PAJOUHESH DAR PEZESHKI, 27(2), 103-111. SID. https://sid.ir/paper/42175/en

Vancouver: Copy

NIKMARAM M.R., RICHARD BOYETT M.. REGIONAL DIFFERENCES IN THE ROLE OF HYPERPOLARIZATION-ACTIVATED CURRENT 'IF' IN PACEMAKER POTENTIAL WITHIN THE INTACT SINOATRIAL NODE OF THE HEART IN RABBIT. PAJOUHESH DAR PEZESHKI[Internet]. 2003;27(2):103-111. Available from: https://sid.ir/paper/42175/en

IEEE: Copy

M.R. NIKMARAM, and M. RICHARD BOYETT, “REGIONAL DIFFERENCES IN THE ROLE OF HYPERPOLARIZATION-ACTIVATED CURRENT 'IF' IN PACEMAKER POTENTIAL WITHIN THE INTACT SINOATRIAL NODE OF THE HEART IN RABBIT,” PAJOUHESH DAR PEZESHKI, vol. 27, no. 2, pp. 103–111, 2003, [Online]. Available: https://sid.ir/paper/42175/en

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