HER4 GENE EXPRESSION IN FFPE BREAST CANCER PATIENTS

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SAFARPOUR PARIMA; MOSLEMI ELHAM; ESFAHANI KASRA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Research in Medicine Year:2017 | Volume:41 | Issue:3 Page(s): 210-216

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Information Journal Paper

Title

HER4 GENE EXPRESSION IN FFPE BREAST CANCER PATIENTS

Author(s)

SAFARPOUR PARIMA | MOSLEMI ELHAM | ESFAHANI KASRA | Issue Writer Certificate

Keywords

BREAST CANCERQ2

HER4Q1

REAL-TIME PCRQ2

Abstract

Backgrond: The BREAST CANCER is the second cause of death worldwide. Understanding of the molecular pathology of BREAST CANCER can provide useful information about new treatment routes. HER4 gene considered as a molecular preprognostic marker in cancers recently. So the purpose of this research is studying of HER4 gene expression in BREAST CANCER patients.Materials and Methods: In this study 70 samples of paraffin blocks of 35 samples from BREAST CANCER patients and 35 normal samples were collected. After slicing and deparaffinization, RNA of samples was extracted and then cDNA synthesis using of M-MuLV enzyme and Oligo dt and Random hexamer primers were done. Statistical analysis of research by Graph Pad prism software with the t-test procedure was done. Findings: Results of REAL-TIME PCR showed HER4 gene expression decreased in most samples compared to normal ones and It was determined that gene expression has the inverse relation to progression in cancer stage. Therefore, in the samples with first and second stage HER4 gene expression increased 1.11 (P value 0.048) compared with normal ones and in the third and fourth stage HER4 gene expression 0.624 (P value 0.048) decreased. Conclusion: According to the results, the study of HER4 gene expression may have a role as a diagnostic marker in BREAST CANCER. In addition, these data can be effective in identifying and diagnosing of disease in early stages.

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APA: Copy

SAFARPOUR, PARIMA, MOSLEMI, ELHAM, & ESFAHANI, KASRA. (2017). HER4 GENE EXPRESSION IN FFPE BREAST CANCER PATIENTS. PAJOUHESH DAR PEZESHKI, 41(3 ), 210-216. SID. https://sid.ir/paper/42197/en

Vancouver: Copy

SAFARPOUR PARIMA, MOSLEMI ELHAM, ESFAHANI KASRA. HER4 GENE EXPRESSION IN FFPE BREAST CANCER PATIENTS. PAJOUHESH DAR PEZESHKI[Internet]. 2017;41(3 ):210-216. Available from: https://sid.ir/paper/42197/en

IEEE: Copy

PARIMA SAFARPOUR, ELHAM MOSLEMI, and KASRA ESFAHANI, “HER4 GENE EXPRESSION IN FFPE BREAST CANCER PATIENTS,” PAJOUHESH DAR PEZESHKI, vol. 41, no. 3 , pp. 210–216, 2017, [Online]. Available: https://sid.ir/paper/42197/en

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