EFFECT OF CAPTOPRIL ON AQUEOUS LEVELS OF ANGIOTENSIN II IN DIABETIC PATIENTS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SHAHSHAHAN S.M.; PEYMAN M.R.; GHANBARI HESHMAT ELAH; PEYMAN A.R.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: BINA Year:2006 | Volume:11 | Issue:3 (44) Page(s): 301-306

Download Full-Text

Persian Verion

View:

881

Download:

Cites:

Information Journal Paper

Title

EFFECT OF CAPTOPRIL ON AQUEOUS LEVELS OF ANGIOTENSIN II IN DIABETIC PATIENTS

Author(s)

SHAHSHAHAN S.M. | PEYMAN M.R. | GHANBARI HESHMAT ELAH | PEYMAN A.R. | Issue Writer Certificate

Keywords

AQUEOUSQ3

ANGIOTENSIN IIQ3

DIABETIC MACULAR EDEMAQ3

CAPTOPRILQ3

Abstract

Purpose: To determine whether ANGIOTENSIN II levels in AQUEOUS humor is related to diabetes mellitus and to evaluate the effect of CAPTOPRIL.Methods: In a case-control study, AQUEOUS humor samples were obtained during cataract surgery from 58 eyes of 58 patients, of which 37 were diabetic. From these latter subjects, 16 had taken CAPTOPRIL (captopril group) and 21 had not taken any angiotensin converting enzyme (ACE) inhibitor (non-captopril group). Angiotensin level was assessed by radioimmunoassay. Severity of macular edema was evaluated by clinical examination after surgery. Mann Whitney U test was used to assess the statistical difference of mean ANGIOTENSIN II and HbA1C levels between the groups and Spearman's rank-order correlation coefficient was used to evaluate the correlation between AQUEOUS levels of ANGIOTENSIN II and severity of macular edema.Results: The AQUEOUS level of ANGIOTENSIN II was significantly higher in diabetic patients (31.0±7.3 pg/ml) compared to non-diabetics (6.28±2.8pg/ml). (P<0.0001) AQUEOUS concentration of ANGIOTENSIN II in the CAPTOPRIL group (16.3±6.5mg/ml) was significantly lower than in the noncaptopril group (75.73±9.36). (P<0.0003) Severity of macular edema was significantly lower in the CAPTOPRIL group as compared to the non-captopril group such that 68.75% of the CAPTOPRIL group vs 33.3% of the non-captopril group had no macular edema (P<0.005).Conclusion: These findings suggest that the AQUEOUS level of angiotens in II is significantly correlated with the severity of macular edema and may have a role in pathogenesis of macular edema in diabetic patients. It seems that modulation of the renin-angiotens in system may become e very important target for medical treatment in patients with DIABETIC MACULAR EDEMA.

Cites

No record.

References

No record.

Cite

APA: Copy

SHAHSHAHAN, S.M., PEYMAN, M.R., GHANBARI, HESHMAT ELAH, & PEYMAN, A.R.. (2006). EFFECT OF CAPTOPRIL ON AQUEOUS LEVELS OF ANGIOTENSIN II IN DIABETIC PATIENTS. BINA, 11(3 (44)), 301-306. SID. https://sid.ir/paper/42391/en

Vancouver: Copy

SHAHSHAHAN S.M., PEYMAN M.R., GHANBARI HESHMAT ELAH, PEYMAN A.R.. EFFECT OF CAPTOPRIL ON AQUEOUS LEVELS OF ANGIOTENSIN II IN DIABETIC PATIENTS. BINA[Internet]. 2006;11(3 (44)):301-306. Available from: https://sid.ir/paper/42391/en

IEEE: Copy

S.M. SHAHSHAHAN, M.R. PEYMAN, HESHMAT ELAH GHANBARI, and A.R. PEYMAN, “EFFECT OF CAPTOPRIL ON AQUEOUS LEVELS OF ANGIOTENSIN II IN DIABETIC PATIENTS,” BINA, vol. 11, no. 3 (44), pp. 301–306, 2006, [Online]. Available: https://sid.ir/paper/42391/en

Related Journal Papers