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Title

PENETRATING KERATOPLASTY IN YOUNG CHILDREN WITH CONGENITAL HEREDITARY ENDOTHELIAL DYSTROPHY

Pages

  10-18

Abstract

 Purpose: Penetrating keratoplasty in children has been reported with variable results. This study reports the visual results and success rate of PKP in a series of young children with CHED.Patients and methods: In a retrospective study, children less than 12 years old who underwent PKP and were followed at least for 6 months post-operatively, were recalled. They were operated between 1987-1997 by one surgeon. Demographic characteristics of the patients, indication for PKP, pre and post-op management along with final VISUAL OUTCOME and graft clarity were evaluated. Visual result was evaluated by McNemmar test and graft survival by Kaplan-Meyer analysis. Linear regression was used for evaluating the correlation of VISUAL OUTCOME and age at which PKP was done.Results: Twenty-four eyes of 15 patients (7 males and 8 females) were operated. Age of patients at the time of diagnosis was 6.5± 3.6 years. The first PKP was performed at 8.1± 2.5 years of age. Mean follow-up period was 35.5 ±36.2 months. Pre and Post operative VA could be evaluated with Snellen chart in 19 eyes of these cases. Pre-op VA was 20/80 or less in all cases, which decreased to 44.4% post operatively (P<0.002). Post-op VA improved in 94.7% of the eyes. There was no relation between age at which PKP was done and final VISUAL OUTCOME (R2= 0.007). At the last examination, 19 of 23 corneal grafts were clear (82.6%) while 3 cases were hazy (13%) and one was opaque (4%). Allograft rejection was seen in 10 eyes (43.4%) of which 7 were endothelial. All graft failures were due to endothelial rejection. The probability of first graft survival was estimated to be 88% at 3 years and the overall survival rate was 55%.Conclusion: PKP for CHED in children has an acceptable VISUAL OUTCOME and surgical success rate, but appropriate timing for achieving the best results is still controversial.

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    APA: Copy

    ZAMANI, M., JAVADI, M.A., BARADARAN RAFIEI, ALI REZA, KARIMIAN, F., ZARE, M., EYN ELAHI, BAHRAM, ADIBI, B., REZAEI, A., & JAFARINASAB, M.. (2001). PENETRATING KERATOPLASTY IN YOUNG CHILDREN WITH CONGENITAL HEREDITARY ENDOTHELIAL DYSTROPHY . BINA, 7(1), 10-18. SID. https://sid.ir/paper/42503/en

    Vancouver: Copy

    ZAMANI M., JAVADI M.A., BARADARAN RAFIEI ALI REZA, KARIMIAN F., ZARE M., EYN ELAHI BAHRAM, ADIBI B., REZAEI A., JAFARINASAB M.. PENETRATING KERATOPLASTY IN YOUNG CHILDREN WITH CONGENITAL HEREDITARY ENDOTHELIAL DYSTROPHY . BINA[Internet]. 2001;7(1):10-18. Available from: https://sid.ir/paper/42503/en

    IEEE: Copy

    M. ZAMANI, M.A. JAVADI, ALI REZA BARADARAN RAFIEI, F. KARIMIAN, M. ZARE, BAHRAM EYN ELAHI, B. ADIBI, A. REZAEI, and M. JAFARINASAB, “PENETRATING KERATOPLASTY IN YOUNG CHILDREN WITH CONGENITAL HEREDITARY ENDOTHELIAL DYSTROPHY ,” BINA, vol. 7, no. 1, pp. 10–18, 2001, [Online]. Available: https://sid.ir/paper/42503/en

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