ADDITIVE EFFECT OF ERYTHROPOIETIN ON CONVENTIONAL TREATMENT OF METHANOL INDUCED TOXIC OPTIC NEUROPATHY

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PAKRAVAN M.; ESFANDIARI H.; SANJARI N.; GHAHARI E.; HASSANPOUR K.

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Journal: BINA Year:2017 | Volume:22 | Issue:3 Page(s): 218-225

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Title

ADDITIVE EFFECT OF ERYTHROPOIETIN ON CONVENTIONAL TREATMENT OF METHANOL INDUCED TOXIC OPTIC NEUROPATHY

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Keywords

ERYTHROPOIETINQ3

METHANOL-INDUCED TOXIC OPTIC NEUROPATHYQ3

TOXIC NEUROPATHYQ3

Abstract

Purpose: To investigate the effect of intravenous ERYTHROPOIETIN (EPO) in adjunction to intravenous steroid and conventional treatment protocol in patients with MTON.Methods: In this non-randomized prospective interventional comparative case series, eleven patients diagnosed with MTON, received intravenous EPO (10000 IU twice a day) for 3 days combined with intravenous methylprednisolone (500 mg twice a day for 5 days) followed by oral prednisolone 1mg/kg for two weeks, and vitamin B12, B6 and folic acid (EPO group). These patients were compared with a historical control group who had received similar treatment except EPO. Our main outcome measures were Best-Corrected Visual Acuity (BCVA), Peripapillary Retinal Nerve Fiber Layer Thickness (PRNFLT), and visual field Mean Deviation (MD).Results: Patients in both groups had better final BCVA at the third month. Mean BCVA improved significantly from 2.93±0.55 to 1.75±1.16 LogMAR at month 3 (p<0.001) in the EPO group and from 2.65±0.68 to 2.19±0.75 at final visit in the control group (p=0.001). Comparing two groups, Final BCVA was significantly better in the EPO group (P=0.012). Although the mean PRNFLT decreased in both groups, it was significantly thinner in the control group at final follow-up (53±6 vs.77±26 microns, respectively; p<0.001).Conclusion: Intravenous EPO in combination with systemic steroid appears to be an effective treatment in patients with MTON. This combinational therapy may supplement additional benefits to the systemic steroid regimen.

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APA: Copy

PAKRAVAN, M., ESFANDIARI, H., SANJARI, N., GHAHARI, E., & HASSANPOUR, K.. (2017). ADDITIVE EFFECT OF ERYTHROPOIETIN ON CONVENTIONAL TREATMENT OF METHANOL INDUCED TOXIC OPTIC NEUROPATHY. BINA, 22(3 ), 218-225. SID. https://sid.ir/paper/42631/en

Vancouver: Copy

PAKRAVAN M., ESFANDIARI H., SANJARI N., GHAHARI E., HASSANPOUR K.. ADDITIVE EFFECT OF ERYTHROPOIETIN ON CONVENTIONAL TREATMENT OF METHANOL INDUCED TOXIC OPTIC NEUROPATHY. BINA[Internet]. 2017;22(3 ):218-225. Available from: https://sid.ir/paper/42631/en

IEEE: Copy

M. PAKRAVAN, H. ESFANDIARI, N. SANJARI, E. GHAHARI, and K. HASSANPOUR, “ADDITIVE EFFECT OF ERYTHROPOIETIN ON CONVENTIONAL TREATMENT OF METHANOL INDUCED TOXIC OPTIC NEUROPATHY,” BINA, vol. 22, no. 3 , pp. 218–225, 2017, [Online]. Available: https://sid.ir/paper/42631/en

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