INTRAVITREAL CARBOPLATIN FOR INTRAOCULAR RETINOBLASTOMA

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KARKHANEH R.; MORADI MOGHADAM MARZIEH; SHAMS HORMOZ; VOSOUGH PARVANEH; VELAEI N.

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Journal: BINA Year:2001 | Volume:6 | Issue:2 Page(s): 95-105

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Title

INTRAVITREAL CARBOPLATIN FOR INTRAOCULAR RETINOBLASTOMA

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Keywords

CARBOPLATINQ3

RETINOBLASTOMAQ3

INTRAVITREALQ3

Abstract

Purpose: To evaluate the role of INTRAVITREAL injection of CARBOPLATIN in the management of intraocular RETINOBLASTOMA in patients referring to Farabi Eye Hospital during 1999-2000. Patients and methods: This is a randomized double-blind matched clinical trial. Definite diagnosis of intraocular RETINOBLASTOMA was made based on clinical examination, ultrasonography or orbital CT-scanning tomography. A comprehensive ophthalmic examination was performed with the patient under general anesthesia. Anterior chamber, iris, lens, vitreous, retina and intraocular tumors were assessed carefully. The greatest basal diameter and the thickness of each tumor were estimated through indirect ophthalmoloscopy according to disc diameter. After ruling out the exteraocular or systemic metastasis, the eyes were divided into 10 blocks according to Reese-Ellswrth classification and then the eyes in each block were divided randomly into two groups; the control group and the case group. The control group only received systemic chemotherapy including vincristine, etoposide, and CARBOPLATIN (VEC) at least for 6 sessions. The case group received the same chemotherapy plus INTRAVITREAL CARBOPLATIN. The INTRAVITREAL CARBOPLATIN administered as 2 injection of 5 mcg with 2 weeks interval. All patients were reexamined under general anesthesia monthly and the greatest basal diameter and the thickness of each tumor and the vitreous status were reassessed each time and when the volume of tumor reduced, laser therapy was performed. All examinations were done by a single physician. The results were compared and analyzed with Chi-square, Fisher exact test, and T-test. Results: This study was conducted on 45 tumors in 19 eyes of 13 patients. In the control group there were 20 tumors in 8 eyes and in the case group there were 25 tumors in 11 eyes. There was 1.8±l.8 disc diameter or 81% decrease in tumor thickness in the case group (P<0.001)that was two times greater than in control group (P<0.09). There was 56% decrease in the greatest basal diameter of the tumors in the case group. About 91% of the eyes in the case group and 75% of the eyes in the control group saved from enucleation. In the control group 6 eyes had advanced stages of tumor (Reese-Ellsworth group IV, V) which two of them were enucleated and in the case group from 6 eyes which had advanced stages of tumor just one eye was enucleated. Conclusion: INTRAVITREAL CARBOPLATIN plus systemic chemotherapy using VEC inhibited the tumor growth more effectively in comparison with systemic chemotherapy alone.

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APA: Copy

KARKHANEH, R., MORADI MOGHADAM, MARZIEH, SHAMS, HORMOZ, VOSOUGH, PARVANEH, & VELAEI, N.. (2001). INTRAVITREAL CARBOPLATIN FOR INTRAOCULAR RETINOBLASTOMA. BINA, 6(2), 95-105. SID. https://sid.ir/paper/42763/en

Vancouver: Copy

KARKHANEH R., MORADI MOGHADAM MARZIEH, SHAMS HORMOZ, VOSOUGH PARVANEH, VELAEI N.. INTRAVITREAL CARBOPLATIN FOR INTRAOCULAR RETINOBLASTOMA. BINA[Internet]. 2001;6(2):95-105. Available from: https://sid.ir/paper/42763/en

IEEE: Copy

R. KARKHANEH, MARZIEH MORADI MOGHADAM, HORMOZ SHAMS, PARVANEH VOSOUGH, and N. VELAEI, “INTRAVITREAL CARBOPLATIN FOR INTRAOCULAR RETINOBLASTOMA,” BINA, vol. 6, no. 2, pp. 95–105, 2001, [Online]. Available: https://sid.ir/paper/42763/en

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