THE IMPACTS OF SIMPLE FEBRILE SEIZURE ON APOPTOSIS RELATED MOLECULAR CHANGES IN HIPPOCAMPUS OF RAT NEONATES

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SAEEDI BORUJENI M.; SAZEGAR G.; HAMI J.; RASTIN M.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Archives of Rehabilitation (Journal of Rehabilitation) Year:2013 | Volume:14 | Issue:3 (58) Page(s): 88-95

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

582

Download:

Cites:

Information Journal Paper

Title

THE IMPACTS OF SIMPLE FEBRILE SEIZURE ON APOPTOSIS RELATED MOLECULAR CHANGES IN HIPPOCAMPUS OF RAT NEONATES

Author(s)

SAEEDI BORUJENI M. | SAZEGAR G. | HAMI J. | RASTIN M. | Issue Writer Certificate

Keywords

SIMPLE FEBRILE SEIZUREQ2

HIPPOCAMPUSQ2

APOPTOSISQ2

Abstract

Objective: Febrile seizures are the most common seizure disorder in childhood, and occur in 2-5% of children.While SIMPLE FEBRILE SEIZUREs are frequently described as inoffensive disorder; there are evidence suggesting the association between SIMPLE FEBRILE SEIZUREs and hippocampal abnormalities in adulthood. This study was designed to evaluate the protein levels of Bcl-2 and Bax as two major APOPTOSIS markers, in the rat neonates’ HIPPOCAMPUS due to SIMPLE FEBRILE SEIZURE.Materials & Methods: Febrile seizure was modeled by hyperthermia-induced seizure in 22-day-old male rats using a hot water bath. Animals were divided into two groups based on the presence or absence of seizure behaviours; Hyperthermia without seizure (n=10) and Hyperthermia with seizure (n=10). To control the effects of environmental stress a sham-control group was also added to the study (n=10). The rats’ hippocampi were removed 15 days after hyperthermia. The expression of Bax and Bcl-2 proteins were measured using Western Blot technique.Results: Our results showed that the protein levels of Bcl-2 were significantly lower in HIPPOCAMPUS of hyperthermia with seizure group rats than that of the sham-control and Hyperthermia without seizure groups. Whereas, the levels of Bax protein in hippocampi of hyperthermia with seizure group animals showed a markedly upregulation, when compared to sham-control and Hyperthermia without seizure groups.Conclusion: SIMPLE FEBRILE SEIZURE is associated with changes in the level of Bcl2, and Bax proteins, indicating an APOPTOSIS improvement in hippocampi of juvenile rats, which were measurable for at least 15 days.

Cites

No record.

References

No record.

Cite

APA: Copy

SAEEDI BORUJENI, M., SAZEGAR, G., HAMI, J., & RASTIN, M.. (2013). THE IMPACTS OF SIMPLE FEBRILE SEIZURE ON APOPTOSIS RELATED MOLECULAR CHANGES IN HIPPOCAMPUS OF RAT NEONATES. ARCHIVES OF REHABILITATION (JOURNAL OF REHABILITATION), 14(3 (58)), 88-95. SID. https://sid.ir/paper/43286/en

Vancouver: Copy

SAEEDI BORUJENI M., SAZEGAR G., HAMI J., RASTIN M.. THE IMPACTS OF SIMPLE FEBRILE SEIZURE ON APOPTOSIS RELATED MOLECULAR CHANGES IN HIPPOCAMPUS OF RAT NEONATES. ARCHIVES OF REHABILITATION (JOURNAL OF REHABILITATION)[Internet]. 2013;14(3 (58)):88-95. Available from: https://sid.ir/paper/43286/en

IEEE: Copy

M. SAEEDI BORUJENI, G. SAZEGAR, J. HAMI, and M. RASTIN, “THE IMPACTS OF SIMPLE FEBRILE SEIZURE ON APOPTOSIS RELATED MOLECULAR CHANGES IN HIPPOCAMPUS OF RAT NEONATES,” ARCHIVES OF REHABILITATION (JOURNAL OF REHABILITATION), vol. 14, no. 3 (58), pp. 88–95, 2013, [Online]. Available: https://sid.ir/paper/43286/en

Related Journal Papers