THE STUDY OF ANTIMUTATION AND ANTICARCINOGEN ACTIVITY OF TRITERPENOIDS PRESENTED IN APPLE PEEL (URSOLIC ACID AND OLEANOLIC ACID) USING AMES TEST

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MEHRABIYAN SEDIGHE; KHALILI HAMASE; HASHEMI MEHRDAD

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Journal: JOURNAL OF SCIENCE (KHARAZMI UNIVERSITY) Year:2009 | Volume:9 | Issue:4 Page(s): 603-612

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Title

THE STUDY OF ANTIMUTATION AND ANTICARCINOGEN ACTIVITY OF TRITERPENOIDS PRESENTED IN APPLE PEEL (URSOLIC ACID AND OLEANOLIC ACID) USING AMES TEST

Author(s)

MEHRABIYAN SEDIGHE | KHALILI HAMASE | HASHEMI MEHRDAD | Issue Writer Certificate

Keywords

APPLE PEELQ3

ANTIMUTATION AND ANTICANCER ACTIVITYQ3

OLEANOLIC ACIDQ3

URSOLIC ACIDQ3

SALLMONELLA THYPHIMURIUMQ3

Abstract

The URSOLIC ACID and OLEANOLIC ACID presented in APPLE PEELs have a potential antioxidant acivity. Antiprolifertive acivity of the triterpenoids against human liver cancer cells, breast cancer cells and colon cancer ells is evaluated. In this study, we have used URSOLIC ACID and OLEANOLIC ACID which are predominant isolated triterpenoids of the APPLE PEELs.. The purpose of this study is to determine antimutation and anticarcinogen effect of URSOLIC ACID and OLEANOLIC ACID against Sodium Azide mutagen substance by the use of Microsome and Ames test.These substances were white powder and soluble in Acetone and bought from sigma company. The bacterium used in this test is a strain of Salmonella thyphimurium (TA100) that carries a selective mutation in its Histidine Operon. We also added Microsome to improve anticancer activity of this two triterpenoids. In this study, inhibition percentage from mutation was 83% for URSOLIC ACID and 76.4 % for OLEANOLIC ACID in presence of Microsome ( and 77.6% for URSOLIC ACID and 69.8% for OLEANOLIC ACID in absence of Microsome). Therefore, presence of anti mutation URSOLIC ACID and OLEANOLIC ACID along with mutagen substance reduced quantity of back mutation and Inhibition over 40% recommended as a powerful antimutation substance. Therefore, APPLE PEEL has large amount of active Phytochemicals, with Antimutation and Anticarcinogen activity and URSOLIC ACID has more antimutation activity than OLEANOLIC ACID.

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APA: Copy

MEHRABIYAN, SEDIGHE, KHALILI, HAMASE, & HASHEMI, MEHRDAD. (2009). THE STUDY OF ANTIMUTATION AND ANTICARCINOGEN ACTIVITY OF TRITERPENOIDS PRESENTED IN APPLE PEEL (URSOLIC ACID AND OLEANOLIC ACID) USING AMES TEST. JOURNAL OF SCIENCE (KHARAZMI UNIVERSITY), 9(4), 603-612. SID. https://sid.ir/paper/43979/en

Vancouver: Copy

MEHRABIYAN SEDIGHE, KHALILI HAMASE, HASHEMI MEHRDAD. THE STUDY OF ANTIMUTATION AND ANTICARCINOGEN ACTIVITY OF TRITERPENOIDS PRESENTED IN APPLE PEEL (URSOLIC ACID AND OLEANOLIC ACID) USING AMES TEST. JOURNAL OF SCIENCE (KHARAZMI UNIVERSITY)[Internet]. 2009;9(4):603-612. Available from: https://sid.ir/paper/43979/en

IEEE: Copy

SEDIGHE MEHRABIYAN, HAMASE KHALILI, and MEHRDAD HASHEMI, “THE STUDY OF ANTIMUTATION AND ANTICARCINOGEN ACTIVITY OF TRITERPENOIDS PRESENTED IN APPLE PEEL (URSOLIC ACID AND OLEANOLIC ACID) USING AMES TEST,” JOURNAL OF SCIENCE (KHARAZMI UNIVERSITY), vol. 9, no. 4, pp. 603–612, 2009, [Online]. Available: https://sid.ir/paper/43979/en

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