EFFECT OF HYDROALCOHOLIC EXTRACT OF SAFFRON ON THE FUNCTIONS OF RAT PERITONEAL MACROPHAGES

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DAMYA NARGES; KHEZRI SHIVA; ABTAHI FROUSHANI SEYYED MEYSAM

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2018 | Volume:28 | Issue:159 Page(s): 14-22

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Title

EFFECT OF HYDROALCOHOLIC EXTRACT OF SAFFRON ON THE FUNCTIONS OF RAT PERITONEAL MACROPHAGES

Author(s)

DAMYA NARGES | KHEZRI SHIVA | ABTAHI FROUSHANI SEYYED MEYSAM | Issue Writer Certificate

Keywords

SAFFRONQ1

CROCUS SATIVUSQ2

MACROPHAGEQ2

CYTOKINEQ2

RATQ2

Abstract

Background and purpose: SAFFRON (Crocus sativus) is a medicinal plant with anti-inflammatoryeffects. MACROPHAGEs are major cells that participate in inflammatory and immunity responses. Thepresent study was performed to investigate the immunomodulatory effects of hydro-alcoholic extract ofSAFFRON on RAT peritoneal MACROPHAGEs. Materials and methods: This experimental study was conducted in two groups of male RATs; anexperimental and a control group. The animals in treatment group received hydro-alcoholic extract ofSAFFRON for 4 constitutive weeks (400 mg/kg-daily, orally). The control RATs received the same volume ofdistilled water. At the end of the study, MACROPHAGEs were isolated from peritoneal cavity of RATs andchallenged with opsonized yeast. Then, the MACROPHAGEs were evaluated for the RATe of respiratory burst, nitric oxide production, and CYTOKINE production using nitro-blue tetrazolium reduction assay, Griess test, and ELISA, respectively. Results: The results of stimulation of MACROPHAGEs showed a significant decrease in respiratoryburst (P<0. 001) and nitric oxide production (P<0. 01) in MACROPHAGEs isolated from treatment groupscompared to that in control RATs. Nevertheless, the results of phagocytosis assay and vitality did not showany significant differences between MACROPHAGEs in controls and treatment group. Moreover, SAFFRONcaused a significant increase in production of anti-inflammatory IL-10 by MACROPHAGEs isolated fromtreatment group (P<0. 01). The level of pro-inflammatory IL-12 did not alter significantly. But, the IL-12to IL-10 RATio decreased significantly (P<0. 01). Conclusion: It seems that SAFFRON is a natural source to intervene the damages caused byinflammatory MACROPHAGEs in immunopathological conditions.

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APA: Copy

DAMYA, NARGES, KHEZRI, SHIVA, & ABTAHI FROUSHANI, SEYYED MEYSAM. (2018). EFFECT OF HYDROALCOHOLIC EXTRACT OF SAFFRON ON THE FUNCTIONS OF RAT PERITONEAL MACROPHAGES. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 28(159 ), 14-22. SID. https://sid.ir/paper/44161/en

Vancouver: Copy

DAMYA NARGES, KHEZRI SHIVA, ABTAHI FROUSHANI SEYYED MEYSAM. EFFECT OF HYDROALCOHOLIC EXTRACT OF SAFFRON ON THE FUNCTIONS OF RAT PERITONEAL MACROPHAGES. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;28(159 ):14-22. Available from: https://sid.ir/paper/44161/en

IEEE: Copy

NARGES DAMYA, SHIVA KHEZRI, and SEYYED MEYSAM ABTAHI FROUSHANI, “EFFECT OF HYDROALCOHOLIC EXTRACT OF SAFFRON ON THE FUNCTIONS OF RAT PERITONEAL MACROPHAGES,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 159 , pp. 14–22, 2018, [Online]. Available: https://sid.ir/paper/44161/en

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