EFFECTS OF CADMIUM ON OXIDATIVE STRESS MARKERS, AND INSULIN SECRETION AND CONTENT IN PANCREATIC ISOLATED ISLET OF RATS

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Sargazi Mojtaba; ZAL FATEMEH; KARBALAEI NARGES

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Journal: Journal of Mazandaran University of Medical Sciences Year:2018 | Volume:27 | Issue:158 Page(s): 1-14

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Title

EFFECTS OF CADMIUM ON OXIDATIVE STRESS MARKERS, AND INSULIN SECRETION AND CONTENT IN PANCREATIC ISOLATED ISLET OF RATS

Author(s)

Sargazi Mojtaba | ZAL FATEMEH | KARBALAEI NARGES | Issue Writer Certificate

Keywords

CADMIUMQ2

INSULIN SECRETIONQ2

OXIDATIVE STRESSQ2

PANCREATIC ISOLATED ISLETQ2

RATQ2

Abstract

Background and purpose: CADMIUM is a highly toxic industrial and environmental pollutantthat is known as an important risk factor for developing diabetes. OXIDATIVE STRESS is reported to be highlyassociated with diabetes and its complications. The aim of this study was to evaluate the effects ofCADMIUM on OXIDATIVE STRESS response and secretory function of islets of Langerhans from RAT pancreas. Materials and methods: Male Sprague-Dawley RATs weighing 260-230 g, were divided into twogroups, including a control and an experimental group that received CADMIUM chloride. Afterintraperitoneal glucose tolerance test (IPGTT) on day 30, the animals were deeply anesthetized and thepancreas was removed for pancreatic islet isolation. OXIDATIVE STRESS, islet insulin content and secretionwere also evaluated in pancreas. Results: The findings showed a significant increase in blood glucose concentration andsignificant decreases in body weight, blood insulin level, insulin content, and secretion of pancreatic isletin response to glucose concentrations in CADMIUM exposed group compared with those of the controlgroup (P< 0. 05). We found that the effects of CADMIUM on the parameters of OXIDATIVE STRESS led to asignificant increase in level of MDA and significant decrease in GSH and activity of antioxidant enzymesin pancreas tissue (P< 0. 05). Conclusion: In this study, CADMIUM led to increase in OXIDATIVE STRESS which can be an importantfactor in the decreased insulin synthesis and secretion from pancreatic beta cells.

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APA: Copy

Sargazi, Mojtaba, ZAL, FATEMEH, & KARBALAEI, NARGES. (2018). EFFECTS OF CADMIUM ON OXIDATIVE STRESS MARKERS, AND INSULIN SECRETION AND CONTENT IN PANCREATIC ISOLATED ISLET OF RATS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 27(158 ), 1-14. SID. https://sid.ir/paper/44183/en

Vancouver: Copy

Sargazi Mojtaba, ZAL FATEMEH, KARBALAEI NARGES. EFFECTS OF CADMIUM ON OXIDATIVE STRESS MARKERS, AND INSULIN SECRETION AND CONTENT IN PANCREATIC ISOLATED ISLET OF RATS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;27(158 ):1-14. Available from: https://sid.ir/paper/44183/en

IEEE: Copy

Mojtaba Sargazi, FATEMEH ZAL, and NARGES KARBALAEI, “EFFECTS OF CADMIUM ON OXIDATIVE STRESS MARKERS, AND INSULIN SECRETION AND CONTENT IN PANCREATIC ISOLATED ISLET OF RATS,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 27, no. 158 , pp. 1–14, 2018, [Online]. Available: https://sid.ir/paper/44183/en

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