EFFECT OF ALCOHOLIC EUPHORBIA CYPARISSIAS EXTRACT ON HISTOLOGIC ALTERNATION IN PROSTATE AND SEMINAL VESICLE IN DIABETIC MODEL

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KOOHI FARDIN; SAFAVI ESMAEIL; NASIRZADEH MOHAMMADREZA

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2018 | Volume:27 | Issue:158 Page(s): 193-199

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Title

EFFECT OF ALCOHOLIC EUPHORBIA CYPARISSIAS EXTRACT ON HISTOLOGIC ALTERNATION IN PROSTATE AND SEMINAL VESICLE IN DIABETIC MODEL

Author(s)

KOOHI FARDIN | SAFAVI ESMAEIL | NASIRZADEH MOHAMMADREZA | Issue Writer Certificate

Keywords

E.CYPARISSIASQ1

DIABETESQ2

PROSTATEQ2

SEMINAL VESICLEQ2

RATQ2

Abstract

Background and purpose: DIABETES causes adverse effects on the activity of reproductivesystem, including impaired spermatogenesis, decreased sperm count, testosterone serum, seminal fluidvolume, and loss of sexual desire. The aim of this study was to evaluate the effect of E. cyparissias extracton tissue changes of PROSTATE and vesicle seminal in diabetic RATs. Materials and methods: Thirty male Wistar RATs were randomly selected and divided into threegroups (n=10), including a control group (healthy animals), a diabetic group and a treatment group. DIABETES was induced by streptozotocin in treatment group and the animals received E. cyparissias extract(500 mg/kg) for 28 days by oral gavage. Then, the samples of PROSTATE and vesicle seminal tissue weretaken and prepared for histological study using light microscope. Results: Morphology findings showed increase in secretion and in diameter of tubules anddecrease in interstitial space of PROSTATE and vesicle seminal in treatment group compared with those ofthe diabetic group. Histomorphometric results indicated significant increases in epithelium height, diameter of the tubules of the PROSTATE and thickness of the muscle layer of SEMINAL VESICLEs in treatmentgroup compared with those in diabetic group (P˂ 0. 05). The study also revealed that gland weight to bodyweight in treatment group increased significantly compared with that of the diabetic group (P˂ 0. 05). Conclusion: According to current findings, oral administration of E. cyparissias extractprevented diabetic induced tissue changes in PROSTATE and SEMINAL VESICLE in RATs.

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APA: Copy

KOOHI, FARDIN, SAFAVI, ESMAEIL, & NASIRZADEH, MOHAMMADREZA. (2018). EFFECT OF ALCOHOLIC EUPHORBIA CYPARISSIAS EXTRACT ON HISTOLOGIC ALTERNATION IN PROSTATE AND SEMINAL VESICLE IN DIABETIC MODEL. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 27(158 ), 193-199. SID. https://sid.ir/paper/44190/en

Vancouver: Copy

KOOHI FARDIN, SAFAVI ESMAEIL, NASIRZADEH MOHAMMADREZA. EFFECT OF ALCOHOLIC EUPHORBIA CYPARISSIAS EXTRACT ON HISTOLOGIC ALTERNATION IN PROSTATE AND SEMINAL VESICLE IN DIABETIC MODEL. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;27(158 ):193-199. Available from: https://sid.ir/paper/44190/en

IEEE: Copy

FARDIN KOOHI, ESMAEIL SAFAVI, and MOHAMMADREZA NASIRZADEH, “EFFECT OF ALCOHOLIC EUPHORBIA CYPARISSIAS EXTRACT ON HISTOLOGIC ALTERNATION IN PROSTATE AND SEMINAL VESICLE IN DIABETIC MODEL,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 27, no. 158 , pp. 193–199, 2018, [Online]. Available: https://sid.ir/paper/44190/en

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