EFFECT OF THREE MAIN POLYMORPHISMS OF VKORC1 GENE ON WARFARIN DOSE REQUIREMENT IN PATIENTS FROM MAZANDARAN PROVINCE

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SALEHIFAR EBRAHIM; FARHADI FAHIMEH; JANBABAI GHASEM; AHANGAR NEMATOLLAH

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Journal: Journal of Mazandaran University of Medical Sciences Year:2012 | Volume:22 | Issue:94 Page(s): 44-52

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Title

EFFECT OF THREE MAIN POLYMORPHISMS OF VKORC1 GENE ON WARFARIN DOSE REQUIREMENT IN PATIENTS FROM MAZANDARAN PROVINCE

Author(s)

SALEHIFAR EBRAHIM | FARHADI FAHIMEH | JANBABAI GHASEM | AHANGAR NEMATOLLAH | Issue Writer Certificate

Keywords

POLYMORPHISMSQ2

WARFARINQ2

VKORC1Q2

INRQ3

Abstract

Background and purpose: The objective of this study was to determine the influence of 3 vitamin K epoxide reductase complex subunit 1 (VKORC1) POLYMORPHISMS (-1639G>A, 1173C>T and 3730G>A) on WARFARIN dose requirement in patients from Mazandaran province, Iran.Materials and methods: A total of 29 patients taking WARFARIN for at least 3 months and had stable dose requirements were enrolled in the study. DNA samples from these patients were genotyped for POLYMORPHISMS in VKORC1 gene and statistical analysis was performed to examine the associations between demographic characteristics (eg, age, sex, weight, height and BMI), genetic factors, and maintenance dose of WARFARIN.Results: In -1639G>A polymorphism, 25 patients (86.2%) were AA, 2 patients (6.9%) were GA and 2 patients (6.9%) were GG genotype. Mean dose of WARFARIN in patients with AA genotype was lower but their INR was higher than two others genotypes. In 1173C>T, 26 patients (89.7%) were TT, 2 patients (6.9%) were CC and one patient (3.4%) was CT. Mean dose of WARFARIN in patients with CT genotype was lower but their INR was higher from two others genotypes. In 3730G>A, 28 patients (96.5%) were GG and only one patient (3.5%) was GA. INR in this patient was higher than other genotype. Significant correlation was obtained only between -1639G>A polymorphism and WARFARIN dose requirement.Conclusion: In the present study, we observed genetic polymorphism in all 3 regions. -1639G>A polymorphism was important determinants of WARFARIN dose requirements in our patients. Correlation between dose requirements and INR with POLYMORPHISMS was similar to other studies; however, percentage of genotypes in each polymorphism was different from other populations.

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APA: Copy

SALEHIFAR, EBRAHIM, FARHADI, FAHIMEH, JANBABAI, GHASEM, & AHANGAR, NEMATOLLAH. (2012). EFFECT OF THREE MAIN POLYMORPHISMS OF VKORC1 GENE ON WARFARIN DOSE REQUIREMENT IN PATIENTS FROM MAZANDARAN PROVINCE. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 22(94), 44-52. SID. https://sid.ir/paper/44207/en

Vancouver: Copy

SALEHIFAR EBRAHIM, FARHADI FAHIMEH, JANBABAI GHASEM, AHANGAR NEMATOLLAH. EFFECT OF THREE MAIN POLYMORPHISMS OF VKORC1 GENE ON WARFARIN DOSE REQUIREMENT IN PATIENTS FROM MAZANDARAN PROVINCE. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2012;22(94):44-52. Available from: https://sid.ir/paper/44207/en

IEEE: Copy

EBRAHIM SALEHIFAR, FAHIMEH FARHADI, GHASEM JANBABAI, and NEMATOLLAH AHANGAR, “EFFECT OF THREE MAIN POLYMORPHISMS OF VKORC1 GENE ON WARFARIN DOSE REQUIREMENT IN PATIENTS FROM MAZANDARAN PROVINCE,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 22, no. 94, pp. 44–52, 2012, [Online]. Available: https://sid.ir/paper/44207/en

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