STUDY ON KAWASAKI DISEASE IN EAST OF MAZANDARAN FROM 1997 TO 2002

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SAFAAR M.J.; GHADER F.R.; JAVERDI A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Paper Information

Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2004 | Volume:14 | Issue:42 Page(s): 108-115

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Title

STUDY ON KAWASAKI DISEASE IN EAST OF MAZANDARAN FROM 1997 TO 2002

Author(s)

SAFAAR M.J. | GHADER F.R. | JAVERDI A. | Issue Writer Certificate

Keywords

MUCOCUTANEOUS LYMPH NODE SYNDROMEQ4

IMMUNOGLOBULINSQ4

COMMUNICABLE DISEASESQ2

Abstract

Background and purpose: Kawasaki disease is the causing agent of acute vasculitis in children with unknown etiology, and at present it is the leading cause of acquired heart diseases in the japenes and North American children. This study is designed to know about the epidemiological, clinical and treatmental features of this disease and its outcome in children living in sari.Materials and methods: This is a descriptive-review done on the files of the kawasaki patients admitted in the East region of Mazandaran hospitals. The criteria for selection of the patients were based on the American heart association diagnostic criteria. Data on individual features, clinical pictures, laboratory findings,treatment and outcome were recorded and analyzed statistically.Results: Of 29 admitted Kawasaki patients, 25 met the criteria for selection. Mean rate of annual incidence of the disease was 7.3 per hundred thousand in children under 5 years. Mean age for occurance was 38±22.3 months and age range was 3.5 to 80 months, in 40% of the cases it occurred in full season, ratio of boys to girls was 1.27/1, mean time between the onset of illness and diagnosis and treatment was 8.2±3.1 days and the least required clinical finding for diagnosis was lymphadenopathy of 73%. Five out of 25 patients had cardiovascular abnormalities (CVA) prior to the beginning of treatment (one with myocarditis and pericarditis, 4 with coronary artery abnormalities). Out of 25 patients, 22 gave response simultaneously to one dose of intravenous injection of immunoglubolin (IVIG) and high dose of aspirin (ASA). Recovery was observed in 2 patients with two doses and one with the third dose of IVIG in a 3 to 12 months period of follow up. All of the patients excluding one completely recovered from cardiovascular complications.Conclusion: In Mazandaran province, Kawasaki disease in one of the most common vasculitis conditions. The prevalence corresponds with the reports given in north America but more that the european countries and less then japan. Although 1/5 of the patients prior to the treatment suffered from cardiovascular abnormalities, most of them responded to the treatment with IVIG and ASA and recovered compaletely within 3 to 12 months follow up.

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