THE RELATIONSHIP BETWEEN EPSTEIN-BARR VIRUS (EBV) AND VIRUS-ENCODED BARF-1 GENE IN GASTRIC ADENOCARCINOMA

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GHASEMI MARYAM; ABEDIAN KENARI SAEID; TORABIZADEH ZHILA; IRI NOUROLDIN; MARJANI JAREN; MIRABI ARAZ MOHAMMAD

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Journal: Journal of Mazandaran University of Medical Sciences Year:2011 | Volume:21 | Issue:82 Page(s): 10-16

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Title

THE RELATIONSHIP BETWEEN EPSTEIN-BARR VIRUS (EBV) AND VIRUS-ENCODED BARF-1 GENE IN GASTRIC ADENOCARCINOMA

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Keywords

EPSTEIN BARR VIRUSQ2

GASTRIC ADENOCARCINOMAQ2

BARF-1Q2

Abstract

Background and purpose: Gastric carcinoma is the second leading cause of cancer death worldwide and its incidence varies considerably according to geographical location. There are multiple etiologic factors such as infection with EBV that play a role in carcinogenesis of gastric cancer, yet there is not enough evidence about pathogenesis of EBV and its relationship with gastric cancer. Thus, recognizing pathogenic genes can help improve the prognosis of the patients. The purpose of this study is to explore the relationship between EBV and EBV-encoded BARF-1 oncogene in GASTRIC ADENOCARCINOMA pathogenesis.Materials and methods: In this analytical case-control study, 200 paraffin-embedded blocks of biopsies of patients with gastric cancer and those of healthy people were selected. After DNA extraction, polymerase chain reaction (PCR) was used to determine EBV genome and BARF-1 oncogene by specific primers of BARF-1. Grade and stage of the gastric cancer biopsies were also examined.Results: The results of PCR indicated that EBV genome was detected in three cases in the case group, whereas all samples in the control group were negative for EBV. Thus, no significant relationship was observed between the two groups (P>0.05). The EBV positive gastric cancers were negative for BARF-1 oncogene. It was also found that 41% of the cancers were grade I, 52% grade II, and 7% grade III.Conclusion: The findings suggest that gastric cancer has a high prevalence in the geographical region under study; however, EBV plays a minor role in the carcinogenesis of GASTRIC ADENOCARCINOMA.

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APA: Copy

GHASEMI, MARYAM, ABEDIAN KENARI, SAEID, TORABIZADEH, ZHILA, IRI, NOUROLDIN, MARJANI, JAREN, & MIRABI, ARAZ MOHAMMAD. (2011). THE RELATIONSHIP BETWEEN EPSTEIN-BARR VIRUS (EBV) AND VIRUS-ENCODED BARF-1 GENE IN GASTRIC ADENOCARCINOMA. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 21(82), 10-16. SID. https://sid.ir/paper/44532/en

Vancouver: Copy

GHASEMI MARYAM, ABEDIAN KENARI SAEID, TORABIZADEH ZHILA, IRI NOUROLDIN, MARJANI JAREN, MIRABI ARAZ MOHAMMAD. THE RELATIONSHIP BETWEEN EPSTEIN-BARR VIRUS (EBV) AND VIRUS-ENCODED BARF-1 GENE IN GASTRIC ADENOCARCINOMA. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2011;21(82):10-16. Available from: https://sid.ir/paper/44532/en

IEEE: Copy

MARYAM GHASEMI, SAEID ABEDIAN KENARI, ZHILA TORABIZADEH, NOUROLDIN IRI, JAREN MARJANI, and ARAZ MOHAMMAD MIRABI, “THE RELATIONSHIP BETWEEN EPSTEIN-BARR VIRUS (EBV) AND VIRUS-ENCODED BARF-1 GENE IN GASTRIC ADENOCARCINOMA,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 21, no. 82, pp. 10–16, 2011, [Online]. Available: https://sid.ir/paper/44532/en

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