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Information Journal Paper

Title

INVESTIGATING THE RADIOSENSITIVITY EFFECT OF DEXTRAN-COATED IRON OXIDE NANOPARTICLES ON CERVICAL CANCEROUS CELLS IRRADIATED WITH 6 MV PHOTON BEAMS

Pages

  162-170

Abstract

 Background and purpose: The use of nanotechnology is increasing in different fields of medical sciences including diagnosis and treatment. METAL NANOPARTICLES such as Iron nanoparticles are proposed as novel RADIATION-SENSITIZING AGENTS in enhancing the efficiency of RADIOTHERAPY because they have a large number of atoms. This study aimed at investigating the radiosensitivity effect of DEXTRAN-coated iron oxide nanoparticles on irradiated cervical cancerous HeLa cell line using 6MV photon beams.Materials and methods: In this experimental study, the cytotoxicity of the nanoparticles on the HeLa cells was measured using MTT assay. To investigate the radiosensitivity effect of the nanoparticles, the cells were incubated with these nanoparticles at 20 and 50mg/ml concentrations and irradiated with different doses of 6MVphoton beams.Results: The incubation times of 6, 12 and 24 hours at concentrations of 20 and 50mg/ml of nanoparticles on the cells did not show significant cytotoxicity. According to the results, DEXTRAN-coated iron oxide nanoparticles showed more radiosensitivity effect at 50μg/ml concentration compared to 20mg/ml. The mean values of dose enhancement factors using 6MV photon beams were 1.19±0.15 and 1.49±0.11, at 20 and 50mg/ml concentrations, respectively.Conclusion: DEXTRAN-coated iron oxide nanoparticles can significantly enhance the radiation absorbed dose and consequently increase RADIOTHERAPY efficiency in cervical cancer cells irradiated with mega voltage photon beam and this could be considered in treatment of cancer.

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    APA: Copy

    MAFAKHEI, HOSSEIN, KHOSHGARD, KARIM, HAGHPARAST, ABBAS, MOSTAFAIE, ALI, EIVAZI, MOHAMMADTAGHI, & REZAEI, MASOUD. (2016). INVESTIGATING THE RADIOSENSITIVITY EFFECT OF DEXTRAN-COATED IRON OXIDE NANOPARTICLES ON CERVICAL CANCEROUS CELLS IRRADIATED WITH 6 MV PHOTON BEAMS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 25(133), 162-170. SID. https://sid.ir/paper/44658/en

    Vancouver: Copy

    MAFAKHEI HOSSEIN, KHOSHGARD KARIM, HAGHPARAST ABBAS, MOSTAFAIE ALI, EIVAZI MOHAMMADTAGHI, REZAEI MASOUD. INVESTIGATING THE RADIOSENSITIVITY EFFECT OF DEXTRAN-COATED IRON OXIDE NANOPARTICLES ON CERVICAL CANCEROUS CELLS IRRADIATED WITH 6 MV PHOTON BEAMS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;25(133):162-170. Available from: https://sid.ir/paper/44658/en

    IEEE: Copy

    HOSSEIN MAFAKHEI, KARIM KHOSHGARD, ABBAS HAGHPARAST, ALI MOSTAFAIE, MOHAMMADTAGHI EIVAZI, and MASOUD REZAEI, “INVESTIGATING THE RADIOSENSITIVITY EFFECT OF DEXTRAN-COATED IRON OXIDE NANOPARTICLES ON CERVICAL CANCEROUS CELLS IRRADIATED WITH 6 MV PHOTON BEAMS,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 25, no. 133, pp. 162–170, 2016, [Online]. Available: https://sid.ir/paper/44658/en

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