USING CHITOSAN/POLYETHYLEN OXIDE (CS/PEO) AS A SCAFFOLD AND WHARTON JELLY-DERIVED MESENCHYMAL STEM CELL TRANSPLANTATION ON THE REPAIR OF TRANSCECTED SCIATIC NERVE IN WISTAR RATS: A BEHAVIORAL AND HISTOLOGICAL STUDY

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MOATTARI MEHRNAZ; KOUCHESFAHANI HOMA; KAKA GHOLAMREZA; SADRAIE HOMAYOUN; NAGHDI MAJID

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Journal: Journal of Mazandaran University of Medical Sciences Year:2016 | Volume:25 | Issue:133 Page(s): 196-205

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Title

USING CHITOSAN/POLYETHYLEN OXIDE (CS/PEO) AS A SCAFFOLD AND WHARTON JELLY-DERIVED MESENCHYMAL STEM CELL TRANSPLANTATION ON THE REPAIR OF TRANSCECTED SCIATIC NERVE IN WISTAR RATS: A BEHAVIORAL AND HISTOLOGICAL STUDY

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Keywords

CHITOSAN SCAFFOLDQ2

WHARTON JELLYQ1

SCIATIC NERVEQ3

REPAIRQ3

Abstract

Background and purpose: The aim of this study was to determine the effects of chitosan/polyethylene oxide (Cs/PEO) scaffold and human mesenchymal stem cells derived from Wharton’s jelly (WJ-hMSCs) on regeneration of the SCIATIC NERVE injury in rats.Materials and methods: In this research, 42 adult male rats were divided into six groups. 1-Normal (intact) group: healthy rats without any nerve transection; 2- Control group: SCIATIC NERVE was cut and sutured; 3- Sham group: culture medium was injected; 4- Cs/PEO group: scaffold with a thin Cs/PEO was used around the injury site; 5- WJ-hMSC group: WJ-hMSCs injected around the site of injury, and 6- WJ-hMSCs-Cs/PEO group: WJ-hMSCs were seeded on Cs/PEO membrane and used around the injury site. Behavioral assessments were done at 2, 4, 6 and 8 weeks following the surgery. Histological evaluation was performed at the end of the study.Results: Our results showed that behavioral values in experimental groups significantly increased when compared to intact group (P<0.05). These values in WJ-hMSC-Cs/PEO group significantly improved compared to the control and sham groups (P<0.05). In addition, histological findings revealed significant increase in the number of nerve fibers in experimental groups compared to intact group (P<0.05). Histological results revealed improvements in groups 4, 5 and 6, however, there was no significant difference between these groups and sham or control group.Conclusion: This study showed the positive effects of chitosan/polyethylene oxide scaffold and human mesenchymal stem cells derived from Wharton’s jelly on nerve regeneration of transected SCIATIC NERVE in rat model.

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APA: Copy

MOATTARI, MEHRNAZ, KOUCHESFAHANI, HOMA, KAKA, GHOLAMREZA, SADRAIE, HOMAYOUN, & NAGHDI, MAJID. (2016). USING CHITOSAN/POLYETHYLEN OXIDE (CS/PEO) AS A SCAFFOLD AND WHARTON JELLY-DERIVED MESENCHYMAL STEM CELL TRANSPLANTATION ON THE REPAIR OF TRANSCECTED SCIATIC NERVE IN WISTAR RATS: A BEHAVIORAL AND HISTOLOGICAL STUDY. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 25(133), 196-205. SID. https://sid.ir/paper/44669/en

Vancouver: Copy

MOATTARI MEHRNAZ, KOUCHESFAHANI HOMA, KAKA GHOLAMREZA, SADRAIE HOMAYOUN, NAGHDI MAJID. USING CHITOSAN/POLYETHYLEN OXIDE (CS/PEO) AS A SCAFFOLD AND WHARTON JELLY-DERIVED MESENCHYMAL STEM CELL TRANSPLANTATION ON THE REPAIR OF TRANSCECTED SCIATIC NERVE IN WISTAR RATS: A BEHAVIORAL AND HISTOLOGICAL STUDY. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;25(133):196-205. Available from: https://sid.ir/paper/44669/en

IEEE: Copy

MEHRNAZ MOATTARI, HOMA KOUCHESFAHANI, GHOLAMREZA KAKA, HOMAYOUN SADRAIE, and MAJID NAGHDI, “USING CHITOSAN/POLYETHYLEN OXIDE (CS/PEO) AS A SCAFFOLD AND WHARTON JELLY-DERIVED MESENCHYMAL STEM CELL TRANSPLANTATION ON THE REPAIR OF TRANSCECTED SCIATIC NERVE IN WISTAR RATS: A BEHAVIORAL AND HISTOLOGICAL STUDY,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 25, no. 133, pp. 196–205, 2016, [Online]. Available: https://sid.ir/paper/44669/en

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