LONG TERM EVALUATION OF ERYTHROPOIETIN EFFECTS ON ISCHEMIA REPERFUSION INJURY AFTER CORONARY ARTERY BYPASS GRAFT SURGERY

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ZIABAKHSH TABARI SHERVIN; JALALIAN ROZITA; MOKHTARI ESBOOEE FARZAD; HABIBI MOHAMMAD REZA; SOLEYMANI ARIA

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2012 | Volume:22 | Issue:89 Page(s): 49-57

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Title

LONG TERM EVALUATION OF ERYTHROPOIETIN EFFECTS ON ISCHEMIA REPERFUSION INJURY AFTER CORONARY ARTERY BYPASS GRAFT SURGERY

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Keywords

ERYTHROPOIETINQ3

CORONARY ARTERY BYPASS GRAFT SURGERYQ2

ISCHEMIA-REPERFUSION INJURYQ2

Abstract

Background and purpose: Recent studies showed that ERYTHROPOIETIN (EPO) despite having role in hematopoiesis, has non-hematopoietic protective effects on ISCHEMIA-REPERFUSION INJURY. this study evaluates the effects of ERYTHROPOIETIN on reducing ischemia-reperfusion injuries during CORONARY ARTERY BYPASS GRAFT SURGERY (CABG).Materials and methods: in this clinical trial, 60 patients candidate for elective CABG were randomly divided into two groups, EPO and control group. Patients in EPO group received IV infusion of EPO (700 IU/kg), at the start of reperfusion after aorta cross clamp. Cardiac markers including Troponin I and Creatine kinase MB (CKMB) assessed eight hours after CABG surgery. Also echocardiography was performed in all patients six month after surgery. the data was analyzed using t-test chi-square and mann-withney.Results: Troponin I level showed no significant difference in EPO and control group (P=0.30). CKMB level in EPO group was higher than that of the control group (P=0.004). Ejection fraction (EF) was also higher in EPO group after six month but it was not significant (P=0.46). Left ventricle end systolic volume (P=0.017) and also Left ventricle end diastolic volume(P=0.04) in EPO group were significantly less in control group.Conclusion: in this study the administration of ERYTHROPOIETIN caused reduction in ischemia-reperfusion injuries after CABG by improving ventricular function, and also reduction in myocardial remodeling and Left ventricle end systolic volume and left ventricle end diastolic volume.

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APA: Copy

ZIABAKHSH TABARI, SHERVIN, JALALIAN, ROZITA, MOKHTARI ESBOOEE, FARZAD, HABIBI, MOHAMMAD REZA, & SOLEYMANI, ARIA. (2012). LONG TERM EVALUATION OF ERYTHROPOIETIN EFFECTS ON ISCHEMIA REPERFUSION INJURY AFTER CORONARY ARTERY BYPASS GRAFT SURGERY. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 22(89), 49-57. SID. https://sid.ir/paper/44709/en

Vancouver: Copy

ZIABAKHSH TABARI SHERVIN, JALALIAN ROZITA, MOKHTARI ESBOOEE FARZAD, HABIBI MOHAMMAD REZA, SOLEYMANI ARIA. LONG TERM EVALUATION OF ERYTHROPOIETIN EFFECTS ON ISCHEMIA REPERFUSION INJURY AFTER CORONARY ARTERY BYPASS GRAFT SURGERY. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2012;22(89):49-57. Available from: https://sid.ir/paper/44709/en

IEEE: Copy

SHERVIN ZIABAKHSH TABARI, ROZITA JALALIAN, FARZAD MOKHTARI ESBOOEE, MOHAMMAD REZA HABIBI, and ARIA SOLEYMANI, “LONG TERM EVALUATION OF ERYTHROPOIETIN EFFECTS ON ISCHEMIA REPERFUSION INJURY AFTER CORONARY ARTERY BYPASS GRAFT SURGERY,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 22, no. 89, pp. 49–57, 2012, [Online]. Available: https://sid.ir/paper/44709/en

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