ASSOCIATION BETWEEN CASPASE-3 GENE POLYMORPHYSM G>A (RS4647603) AND GASTRIC ADENOCARCINOMA IN NORTH OF IRAN

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KHORSHIDI PACHI MARZIYEH; SHOKRZADEH MOHAMMAD

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Journal: Journal of Mazandaran University of Medical Sciences Year:2018 | Volume:27 | Issue:156 Page(s): 20-27

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Title

ASSOCIATION BETWEEN CASPASE-3 GENE POLYMORPHYSM G>A (RS4647603) AND GASTRIC ADENOCARCINOMA IN NORTH OF IRAN

Author(s)

KHORSHIDI PACHI MARZIYEH | SHOKRZADEH MOHAMMAD | Issue Writer Certificate

Keywords

GASTRIC CANCERQ2

APOPTOSISQ1

POLYMORPHISMQ2

CASEPASE 3Q1

Abstract

Background and purpose: GASTRIC CANCER is the second most common cause of cancerworldwide. Having a genetic predisposition plays an important role in cancer development. Defects in theapoptosis way may cause accumulation of immortal cells that ultimately lead to numerous disorders, including cancer. In both domestic and foreign APOPTOSIS ways, CASEPASE 3 plays a key role as executivecasepase. Hence, POLYMORPHISMs in the caspase-3 gene could affect the activity of the gene and also thesusceptibility to GASTRIC CANCER. The purpose of this study was to determine the POLYMORPHISMs ofcaspase-3 gene. Materials and methods: This study was performed in 100 patients with GASTRIC CANCER and also100 healthy people as benchmarks. Genomic DNA was extracted from peripheral blood leukocytes. Thengenotyping of the caspase-3 gene was carried out based on PCR-RFLP method and statistical analysiswas done in MedCalc software V9. Results: In this research, 200 subjects including 115 males and 85 females were studied. Allsubject were well matched for geographic area and race. The results showed a relationship betweenincrease in AG genotype and GASTRIC CANCER (P=0. 02, OR=2. 01, 95% CI (1. 09-3. 69)). Conclusion: Screening of CASEPASE 3 POLYMORPHISM G>A (rs4647603) could be a marker inpersonal sensitivity to GASTRIC CANCER treatment and prevention process.

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APA: Copy

KHORSHIDI PACHI, MARZIYEH, & SHOKRZADEH, MOHAMMAD. (2018). ASSOCIATION BETWEEN CASPASE-3 GENE POLYMORPHYSM G>A (RS4647603) AND GASTRIC ADENOCARCINOMA IN NORTH OF IRAN. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 27(156 ), 20-27. SID. https://sid.ir/paper/44716/en

Vancouver: Copy

KHORSHIDI PACHI MARZIYEH, SHOKRZADEH MOHAMMAD. ASSOCIATION BETWEEN CASPASE-3 GENE POLYMORPHYSM G>A (RS4647603) AND GASTRIC ADENOCARCINOMA IN NORTH OF IRAN. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;27(156 ):20-27. Available from: https://sid.ir/paper/44716/en

IEEE: Copy

MARZIYEH KHORSHIDI PACHI, and MOHAMMAD SHOKRZADEH, “ASSOCIATION BETWEEN CASPASE-3 GENE POLYMORPHYSM G>A (RS4647603) AND GASTRIC ADENOCARCINOMA IN NORTH OF IRAN,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 27, no. 156 , pp. 20–27, 2018, [Online]. Available: https://sid.ir/paper/44716/en

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