Comparing Vitamin B12 and Nitrous Oxide Neurotoxicity in Operating Room Staff and other Hospital Staff: A Multicenter Study

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SADEGHI SAHAR; NOUROZI AFSANEH; AZADI HAMIDREZA; FARAJI FARDIN; Mardani Mahsa; SADEGHI BAHMAN

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2019 | Volume:29 | Issue:173 Page(s): 134-139

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Title

Comparing Vitamin B12 and Nitrous Oxide Neurotoxicity in Operating Room Staff and other Hospital Staff: A Multicenter Study

Author(s)

Keywords

operating room staffQ2

neurotoxicityQ2

nitrous oxideQ3

vitamin B12Q1

Abstract

Background and purpose: nitrous oxide (N2O) is an anesthetic widely used in operating rooms. Chronic exposure to N2O causes decrease in mental performance, peripheral neuropathy, and polyneuropathy. The aim of this study was to compare neurological complications caused by N2O exposure between operating room staff and other hospital staff. Materials and methods: In this multicenter cohort study, operating room staff (n=110) and nonoperating room staff (n= 224) in Arak Valiasr Hospital and Isfahan Al-zahra Hospital were randomly selected and individually matched. Both groups were examined for neuropathic symptoms and their medical history was recorded. Clinical neurological exams such as Romberg test were used in both groups. Patients with neuropathic sign and symptoms were referred to a neurology clinic to confirm any diagnosis. Results: The two groups were significantly different in ataxia, numbness, weakness and paresthesia of upper and lower limb, Romberg test score, and levels of vitamin B12 (P<0. 05). No significant differences were observed between the two groups in mean Hemoglobin level, temperature sense, touch and two-point discrimination, stereo gnosis, tandem walking, and plantar and dorsal flexion (P≥ 0. 05). Conclusion: Chronic exposure to nitrous oxide was found to decrease serum vitamin B12 levels and caused neurological symptoms and complications. Therefore, clinical and laboratory evaluations and monitoring of exposure to nitrous oxide is necessary.

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References

Iron, vitamin B 12 and folate

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APA: Copy

SADEGHI, SAHAR, NOUROZI, AFSANEH, AZADI, HAMIDREZA, FARAJI, FARDIN, Mardani, Mahsa, & SADEGHI, BAHMAN. (2019). Comparing Vitamin B12 and Nitrous Oxide Neurotoxicity in Operating Room Staff and other Hospital Staff: A Multicenter Study. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 29(173 ), 134-139. SID. https://sid.ir/paper/44821/en

Vancouver: Copy

SADEGHI SAHAR, NOUROZI AFSANEH, AZADI HAMIDREZA, FARAJI FARDIN, Mardani Mahsa, SADEGHI BAHMAN. Comparing Vitamin B12 and Nitrous Oxide Neurotoxicity in Operating Room Staff and other Hospital Staff: A Multicenter Study. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;29(173 ):134-139. Available from: https://sid.ir/paper/44821/en

IEEE: Copy

SAHAR SADEGHI, AFSANEH NOUROZI, HAMIDREZA AZADI, FARDIN FARAJI, Mahsa Mardani, and BAHMAN SADEGHI, “Comparing Vitamin B12 and Nitrous Oxide Neurotoxicity in Operating Room Staff and other Hospital Staff: A Multicenter Study,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 29, no. 173 , pp. 134–139, 2019, [Online]. Available: https://sid.ir/paper/44821/en

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