EXPRESSION OF BCL-2 GENE IN PRIMARY BREAST CANCER AND ITS CORRELATION WITH SOME PROGNOSTIC FACTORS

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JALALI NADOUSHAN M.R.; DAVATI A.; TAVAKOLI A.

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Journal: Journal of Mazandaran University of Medical Sciences Year:2007 | Volume:17 | Issue:58 Page(s): 30-36

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Title

EXPRESSION OF BCL-2 GENE IN PRIMARY BREAST CANCER AND ITS CORRELATION WITH SOME PROGNOSTIC FACTORS

Author(s)

JALALI NADOUSHAN M.R. | DAVATI A. | TAVAKOLI A. | Issue Writer Certificate

Keywords

BREAST CANCERQ2

BCL-2Q3

GRADEQ3

STAGEQ2

Abstract

Background and purpose: The BREAST CANCER is the most common malignancy in women. BCL-2 expression has been determined in more than half of the cases of BREAST CANCER. The purpose of this study was to determine the expression of BCL-2 gene in primary BREAST CANCER and its correlation with GRADE, STAGE and axillary lymph node involvement. Materials and Methods: The study was a cross-sectional one that was performed on 75 patients with BREAST CANCER admitted to Mostafa Khomeini hospital (2000-2005). After preparing the samples, a tissue section from each sample was obtained. One of the tumoral sections and one of the lymph node sections were stained using H & E. We determined the type of the tumor, the number of lymph nodes, the STAGE and the GRADE of the tumor. We studied BCL-2 with polyclonal antibody by IHC. Results: Our study showed that 69.3% of patients had hymph node involvment. In addition, 41.3% of samples were positive for BCL-2, 58.7% of samples were in STAGE II and many patients (42.7%) were in GRADE III. In this study, we didn’t find any relationship between BCL-2 and STAGE and lymph node involvment. We also found a significant association between BCL-2 and GRADE (P<0.006). Also, high BCL-2 expression was more frequent in high-grade tumor.Conclusion: According to the results obtained from earlier studies and our study, it seems that bcl2 is a prognostic factor in BREAST CANCER. But further investigations with more specimens and long-time follow-up are required to clarify the exact role of BCL-2 in the prognosis of BREAST CANCER.

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APA: Copy

JALALI NADOUSHAN, M.R., DAVATI, A., & TAVAKOLI, A.. (2007). EXPRESSION OF BCL-2 GENE IN PRIMARY BREAST CANCER AND ITS CORRELATION WITH SOME PROGNOSTIC FACTORS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 17(58), 30-36. SID. https://sid.ir/paper/45113/en

Vancouver: Copy

JALALI NADOUSHAN M.R., DAVATI A., TAVAKOLI A.. EXPRESSION OF BCL-2 GENE IN PRIMARY BREAST CANCER AND ITS CORRELATION WITH SOME PROGNOSTIC FACTORS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2007;17(58):30-36. Available from: https://sid.ir/paper/45113/en

IEEE: Copy

M.R. JALALI NADOUSHAN, A. DAVATI, and A. TAVAKOLI, “EXPRESSION OF BCL-2 GENE IN PRIMARY BREAST CANCER AND ITS CORRELATION WITH SOME PROGNOSTIC FACTORS,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 17, no. 58, pp. 30–36, 2007, [Online]. Available: https://sid.ir/paper/45113/en

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