SIGNIFICANCE AND APPLICATIONS OF MURINE MODELS IN CANCER RESEARCH: GUIDELINES FOR SELECTING THE BEST MODEL

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ABEDI MARJAN; RAHGOZAR SOHEILA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2017 | Volume:27 | Issue:154 Page(s): 212-231

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Title

SIGNIFICANCE AND APPLICATIONS OF MURINE MODELS IN CANCER RESEARCH: GUIDELINES FOR SELECTING THE BEST MODEL

Author(s)

ABEDI MARJAN | RAHGOZAR SOHEILA | Issue Writer Certificate

Keywords

MICE MODELQ2

CANCERQ2

PRECLINICAL STUDIESQ1

IN VIVO ASSAYSQ2

Abstract

Mice are the preferred model organisms in tumor and CANCER research, concerning tumor biology (initiation, progression, and metastasis) or developing and screening the potential therapeutics. Different murine models including genetically engineered mice (GEM), xenografts, and chemical models may be used for this purpose. By reviewing the most recent scientific reports and publications, in the current paper, these models and their applications in different aspects of CANCER research are introduced and their advantages and pitfalls are discussed. This article summarizes the opportunities provided by each model and their limitations and the fundamental differences between mouse and human such as species-specific and pharmacological differences. This article shed light on some key points for selection of the best murine model depending on the purpose of the research.

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APA: Copy

ABEDI, MARJAN, & RAHGOZAR, SOHEILA. (2017). SIGNIFICANCE AND APPLICATIONS OF MURINE MODELS IN CANCER RESEARCH: GUIDELINES FOR SELECTING THE BEST MODEL. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 27(154 ), 212-231. SID. https://sid.ir/paper/45170/en

Vancouver: Copy

ABEDI MARJAN, RAHGOZAR SOHEILA. SIGNIFICANCE AND APPLICATIONS OF MURINE MODELS IN CANCER RESEARCH: GUIDELINES FOR SELECTING THE BEST MODEL. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2017;27(154 ):212-231. Available from: https://sid.ir/paper/45170/en

IEEE: Copy

MARJAN ABEDI, and SOHEILA RAHGOZAR, “SIGNIFICANCE AND APPLICATIONS OF MURINE MODELS IN CANCER RESEARCH: GUIDELINES FOR SELECTING THE BEST MODEL,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 27, no. 154 , pp. 212–231, 2017, [Online]. Available: https://sid.ir/paper/45170/en

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