THE ROLE OF MDR1 IN IMMUNE SYSTEM AND NEURODEGENERATIVE DISORDERS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KHOSRAVI DEHAGHI ZOHREH; ABERUYI NARGES; ABEDI MARJAN; RAHGOZAR SOHEILA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2014 | Volume:24 | Issue:113 Page(s): 12-26

Download Full-Text

Persian Verion

View:

3,717

Download:

Cites:

Information Journal Paper

Title

THE ROLE OF MDR1 IN IMMUNE SYSTEM AND NEURODEGENERATIVE DISORDERS

Author(s)

KHOSRAVI DEHAGHI ZOHREH | ABERUYI NARGES | ABEDI MARJAN | RAHGOZAR SOHEILA | Issue Writer Certificate

Keywords

MDR1Q2

IMMUNE SYSTEMQ2

BLOOD - BRAIN BARRIERQ2

ALZHEIMER’S DISEASEQ2

MULTIPLE SCLEROSISQ2

Abstract

Background and purpose: MDR1 is nowadays considered as a known transporter involved in drug resistance of different cancers. However, the importance of this protein in different systems of the body and its functional role in other diseases is less studied. This article aimed at investigating the role of MDR1 in the IMMUNE SYSTEM and neurological disorders, and also exploring the possible therapeutic use of this protein.Material and Methods: In this review we studied 68 reputable articles published between 1998 and 2014 (both in Persian and English). The search engines included PubMed, Google Scholar, Science Direct and Elsevier databases.Results: The expression of MDR1 increases during the maturation of dendritic cells and their migration to lymph nodes to activate T lymphocytes. The function of this protein has been reported in naive B cells and it is expressed during the activation of CD4+ and CD8+ T lymphocytes. Compared with other leukocyte populations, MDR1 expression levels are the highest in NK cells. MDR1activity in brain capillary endothelial cells, involved in blood-brain barrier, prevents the entry of small drugs and inflammatory molecules into the CNS. The protein expression is reduced in a variety of immune destructive diseases.Conclusion: This article identifies the importance and function of MDR1in brain capillary endothelial cells and those involved in the IMMUNE SYSTEM. Considering the confirmed role of MDR1 in immunological and degenerative disorders, this article may help in resolving the disorders caused by the lack of MDR1expression.

Cites

No record.

References

No record.

Cite

APA: Copy

KHOSRAVI DEHAGHI, ZOHREH, ABERUYI, NARGES, ABEDI, MARJAN, & RAHGOZAR, SOHEILA. (2014). THE ROLE OF MDR1 IN IMMUNE SYSTEM AND NEURODEGENERATIVE DISORDERS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 24(113), 12-26. SID. https://sid.ir/paper/45307/en

Vancouver: Copy

KHOSRAVI DEHAGHI ZOHREH, ABERUYI NARGES, ABEDI MARJAN, RAHGOZAR SOHEILA. THE ROLE OF MDR1 IN IMMUNE SYSTEM AND NEURODEGENERATIVE DISORDERS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2014;24(113):12-26. Available from: https://sid.ir/paper/45307/en

IEEE: Copy

ZOHREH KHOSRAVI DEHAGHI, NARGES ABERUYI, MARJAN ABEDI, and SOHEILA RAHGOZAR, “THE ROLE OF MDR1 IN IMMUNE SYSTEM AND NEURODEGENERATIVE DISORDERS,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 24, no. 113, pp. 12–26, 2014, [Online]. Available: https://sid.ir/paper/45307/en

Related Journal Papers