IDENTIFYING THE FACTORS INFLUENCING THE CAUSES OF DEATH IN HIV/AIDS PATIENTS USING COMPETING RISK MODEL

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IMANI RAZIYE; ROSHANAEI GHODRATOLLAH; POOROLAJAL JALAL; MOLAEYPOOR LEILA

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2018 | Volume:28 | Issue:165 Page(s): 170-174

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Title

IDENTIFYING THE FACTORS INFLUENCING THE CAUSES OF DEATH IN HIV/AIDS PATIENTS USING COMPETING RISK MODEL

Author(s)

IMANI RAZIYE | ROSHANAEI GHODRATOLLAH | POOROLAJAL JALAL | MOLAEYPOOR LEILA | Issue Writer Certificate

Keywords

TUBERCULOSISQ3

HIV/AIDSQ2

CAUSE-SPECIFIC HAZARDSQ2

COMPETING RISKQ1

Abstract

Background and purpose: Mortality in HIV-positive patients is due to various reasons such asprogression to AIDS or co-infection with AIDS and TB or other causes. In survival analysis, competingrisk methods are used if there are different reasons for death. The purpose of this article was to identifythe factors affecting various causes of death using COMPETING RISK methods. Materials and methods: This study was performed in 1231 HIV/AIDS patients attending DiseasesConsulting Centers in Tehran between 2004 and 2013. The cause-specific hazard model was used to studythe effect of factors on death due to co-infection with TB and AIDS and death by other causes. Dataanalysis was performed in R software and cmprsk package. Results: There were 181 patients who were co-infected with TUBERCULOSIS and AIDS. The mediansurvival rate in AIDS-TB patients at the time of diagnosis was 6. 51 ± 0. 66 years and in those with AIDSalone was 11. 56 ± 0. 98 years. The effects of gender (12. 94 [2. 81-59. 97]), CD4 (0. 22 [0. 08-0. 54]), ARTtreatment (0. 42 [0. 24-0. 75]), and isoniazid drug prophylaxis (0. 08 [0. 01-0. 6]) were found to be significanton death due to co-infection with AIDS and TB. Also, the effects of sex (3. 39 [2. 03-5. 66]), CD4 (0. 34[0. 22-0. 51]), ART treatment (0. 32 [0. 23-0. 45]), isoniazid drug prophylaxis (0. 5 [0. 29-0. 85]), and Cotrimoxazoledrug prophylaxis (0. 34 [0. 2-0. 6]) were seen to be significant on death due to other reasons. Conclusion: In this study, the cause-specific hazard model was applied to identify the riskfactors for all causes of death. Therefore, this method could be used to identify the factors influencingcauses of death (separately) and provide solutions to prevent the risks.

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APA: Copy

IMANI, RAZIYE, ROSHANAEI, GHODRATOLLAH, POOROLAJAL, JALAL, & MOLAEYPOOR, LEILA. (2018). IDENTIFYING THE FACTORS INFLUENCING THE CAUSES OF DEATH IN HIV/AIDS PATIENTS USING COMPETING RISK MODEL. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 28(165 ), 170-174. SID. https://sid.ir/paper/45347/en

Vancouver: Copy

IMANI RAZIYE, ROSHANAEI GHODRATOLLAH, POOROLAJAL JALAL, MOLAEYPOOR LEILA. IDENTIFYING THE FACTORS INFLUENCING THE CAUSES OF DEATH IN HIV/AIDS PATIENTS USING COMPETING RISK MODEL. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;28(165 ):170-174. Available from: https://sid.ir/paper/45347/en

IEEE: Copy

RAZIYE IMANI, GHODRATOLLAH ROSHANAEI, JALAL POOROLAJAL, and LEILA MOLAEYPOOR, “IDENTIFYING THE FACTORS INFLUENCING THE CAUSES OF DEATH IN HIV/AIDS PATIENTS USING COMPETING RISK MODEL,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 165 , pp. 170–174, 2018, [Online]. Available: https://sid.ir/paper/45347/en

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