EFFECTS OF QUERCETIN ON SIGNALING PROTEINS (PSTAT3, PERK1.2, PAKT) AND INTERLEUKIN-6 GENE EXPRESSION IN PROSTATE CANCER PC3 CELLS

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HEIDARIAN ESFANDIAR; Amini Sayed Asadollah; ABBASI VELDANI AKRAM; GHATREH SAMANI KEIHAN

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Journal: Journal of Mazandaran University of Medical Sciences Year:2017 | Volume:26 | Issue:144 Page(s): 290-300

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Title

EFFECTS OF QUERCETIN ON SIGNALING PROTEINS (PSTAT3, PERK1.2, PAKT) AND INTERLEUKIN-6 GENE EXPRESSION IN PROSTATE CANCER PC3 CELLS

Author(s)

HEIDARIAN ESFANDIAR | Amini Sayed Asadollah | ABBASI VELDANI AKRAM | GHATREH SAMANI KEIHAN | Issue Writer Certificate

Keywords

INTERLEUKIN-6Q1

CELL LINE PC3Q1

PROSTATE CANCERQ2

QUERCETINQ1

PSTAT3Q1

PERK1.2Q1

PAKTQ1

Abstract

Background and purpose: INTERLEUKIN-6 (IL-6) causes the progression of PROSTATE CANCER through PSTAT3, PERK1.2, and PAKT cell signaling proteins. QUERCETIN, an herbal antioxidant, has antitumor effect. The aim of this study was to evaluate the effects of QUERCETIN on IL-6 gene expression, and the above cellular signaling proteins in PC3 PROSTATE CANCER cells.Materials and methods: In this experimental study, PC3 cells were treated with different concentrations of QUERCETIN at 0, 10, 50, and 100 mM. Then, IL-6 concentration was determined in cell culture media. Also, total RNA and the cellular signaling proteins aforementioned were extracted from PC3 and used for determining IL-6 gene expression by quantitative real-time RT-PCR and western blot analysis, respectively.Results: The QUERCETIN IC50 for PC3 PROSTATE CANCER cells was 100 mM. Elevation of QUERCETIN concentration in cell culture media increased the IL-6 gene expression and protein synthesis. At 50 and 100 mM of QUERCETIN, IL-6 protein synthesis increased significantly (P<0.05) to 13.36% and 36.86%, respectively, compared to those in control. Furthermore, QUERCETIN suppressed PSTAT3, PERK1.2, and PAKT cell signaling proteins at dose concentrations more than 150 mM.Conclusion: The effects of QUERCETIN on PC3 cells could have resulted from reduction of PSTAT3, PERK1.2, PAKT, induction of the oxidative stress and generation of reactive oxygen species. Therefore, QUERCETIN can be considered as a useful therapeutic agent in treatment of PROSTATE CANCER.

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APA: Copy

HEIDARIAN, ESFANDIAR, Amini, Sayed Asadollah, ABBASI VELDANI, AKRAM, & GHATREH SAMANI, KEIHAN. (2017). EFFECTS OF QUERCETIN ON SIGNALING PROTEINS (PSTAT3, PERK1.2, PAKT) AND INTERLEUKIN-6 GENE EXPRESSION IN PROSTATE CANCER PC3 CELLS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 26(144), 290-300. SID. https://sid.ir/paper/45384/en

Vancouver: Copy

HEIDARIAN ESFANDIAR, Amini Sayed Asadollah, ABBASI VELDANI AKRAM, GHATREH SAMANI KEIHAN. EFFECTS OF QUERCETIN ON SIGNALING PROTEINS (PSTAT3, PERK1.2, PAKT) AND INTERLEUKIN-6 GENE EXPRESSION IN PROSTATE CANCER PC3 CELLS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2017;26(144):290-300. Available from: https://sid.ir/paper/45384/en

IEEE: Copy

ESFANDIAR HEIDARIAN, Sayed Asadollah Amini, AKRAM ABBASI VELDANI, and KEIHAN GHATREH SAMANI, “EFFECTS OF QUERCETIN ON SIGNALING PROTEINS (PSTAT3, PERK1.2, PAKT) AND INTERLEUKIN-6 GENE EXPRESSION IN PROSTATE CANCER PC3 CELLS,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 144, pp. 290–300, 2017, [Online]. Available: https://sid.ir/paper/45384/en

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