Comparing the Effect of Dexmedetomidine and Remifentanil on Hemodynamic Indices in Children Undergoing Endotracheal Intubation: A Randomized Clinical Trial

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SHAFA AMIR; SHETABI HAMIDREZA; Askarian Mahdieh

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Journal: Journal of Mazandaran University of Medical Sciences Year:2019 | Volume:28 | Issue:170 Page(s): 74-83

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Title

Comparing the Effect of Dexmedetomidine and Remifentanil on Hemodynamic Indices in Children Undergoing Endotracheal Intubation: A Randomized Clinical Trial

Author(s)

SHAFA AMIR | SHETABI HAMIDREZA | Askarian Mahdieh | Issue Writer Certificate

Keywords

intubationQ3

dexmedetomidineQ1

remifentanilQ3

intranasalQ1

hemodynamicsQ2

Abstract

Background and purpose: Painful stimulation during laryngoscopy and endotracheal intubation results in increased hemodynamic side effects. The aim of current study was to compare the effects of intranasal dexmedetomidine and remifentanil on reduction of hemodynamic changes following endotracheal intubation in children undergoing general anesthesia. Materials and methods: A double-blind clinical trial was performed in 104 children aged 6-12 years old, undergoing general anesthesia in Isfahan Imam Hossein Hospital, Iran, 2017-2018. Patients were randomly assigned into three groups to receive intranasal (IN) remifentanil 4μ g/kg, dexmedetomidine 2μ g/kg (IN), or normal saline 1mL, 0. 9% (IN) before the induction of anesthesia. Hemodynamic changes were recorded at one and five minutes following intubation. ANOVA and Chi-square were applied to analyze the data. Results: Heart rate was higher in patients receiving normal saline and lower in patients receiving dexmedetomidine (p=0. 22). Mean arterial blood pressure (p=0. 98) and arterial oxygenation (p=0. 81) were not significantly different between the three groups. No significant side effects were observed in any group. Conclusion: Administration of pre-intubation intranasal dexmedetomidine, results in heart rate stabilization following intubation.

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APA: Copy

SHAFA, AMIR, SHETABI, HAMIDREZA, & Askarian, Mahdieh. (2019). Comparing the Effect of Dexmedetomidine and Remifentanil on Hemodynamic Indices in Children Undergoing Endotracheal Intubation: A Randomized Clinical Trial. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 28(170 ), 74-83. SID. https://sid.ir/paper/45439/en

Vancouver: Copy

SHAFA AMIR, SHETABI HAMIDREZA, Askarian Mahdieh. Comparing the Effect of Dexmedetomidine and Remifentanil on Hemodynamic Indices in Children Undergoing Endotracheal Intubation: A Randomized Clinical Trial. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;28(170 ):74-83. Available from: https://sid.ir/paper/45439/en

IEEE: Copy

AMIR SHAFA, HAMIDREZA SHETABI, and Mahdieh Askarian, “Comparing the Effect of Dexmedetomidine and Remifentanil on Hemodynamic Indices in Children Undergoing Endotracheal Intubation: A Randomized Clinical Trial,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 170 , pp. 74–83, 2019, [Online]. Available: https://sid.ir/paper/45439/en

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